Long-term coarse particulate matter exposure is associated with asthma among children in medicaid

Corinne A. Keet, Joshua P. Keller, Roger D. Peng

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Rationale: Short- and long-term fine particulate matter (particulate matter <2.5 mm in aerodynamic diameter [PM2.5]) pollution is associated with asthma development and morbidity, but there are few data on the effects of long-term exposure to coarsePM(PM10- 2.5 ) on respiratory health. Objectives: To understand the relationship between long-term fine and coarse PM exposure and asthma prevalence and morbidity among children. Methods: A semiparametric regression model that incorporated PM 2.5 and PM 10 monitor data and geographic characteristics was developed to predict 2-year averagePM 2.5 andPM 10 - 2.5 exposure during the period 2009 to 2010 at the zip-code tabulation area level. Data from 7,810,025 children aged 5 to 20 years enrolled in Medicaid from 2009 to 2010 were used in a log-linear regression model with predicted PM levels to estimate the association between PM exposure and asthma prevalence and morbidity, adjusting for race/ethnicity, sex, age, area-level urbanicity, poverty, education, and unmeasured spatial confounding. Measurements and Main Results: Exposure to coarse PM was associated with increased asthma diagnosis prevalence (rate ratio [RR] for 1-μg/m 3 increase in coarse PM level, 1.006; 95% confidence interval [CI], 1.001-1.011), hospitalizations (RR, 1.023; 95% CI, 1.003-1.042), and emergency department visits (RR, 1.017; 95% CI, 1.001-1.033) when adjusting for fine PM. Fine PM exposure was more strongly associated with increased asthma prevalence and morbidity than coarse PM. The estimates remained elevated across different levels of spatial confounding adjustment. Conclusions: Among children enrolled in Medicaid, exposure to higher average coarse PM levels is associated with increased asthma prevalence and morbidity. These results suggest the need for direct monitoring of coarse PM and reconsideration of limits on long-term average coarse PM pollution levels.

Original languageEnglish (US)
Pages (from-to)737-746
Number of pages10
JournalAmerican journal of respiratory and critical care medicine
Issue number6
StatePublished - Mar 15 2018


  • Air pollution
  • Asthma
  • Particulate matter

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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