Long-term bone mineral density changes in antiretroviral-treated HIV-infected individuals

Philip M. Grant; Douglas Kitch; Grace A. McComsey; Ann C. Collier; Susan L. Koletar; Kristine M. Erlandson; Michael T. Yin; Benedetta Bartali; Belinda Ha; Kathy Melbourne; Todd T. Brown

doi:10.1093/infdis/jiw204

Long-term bone mineral density changes in antiretroviral-treated HIV-infected individuals

Philip M. Grant, Douglas Kitch, Grace A. McComsey, Ann C. Collier, Susan L. Koletar, Kristine M. Erlandson, Michael T. Yin, Benedetta Bartali, Belinda Ha, Kathy Melbourne, Todd T. Brown

School of Medicine

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

We compared adjusted bone mineral density (BMD) changes between human immunodeficiency virus (HIV)-infected individuals during the first approximately 7.5 years after antiretroviral therapy (ART) initiation and HIV-uninfected controls. HIV-infected individuals (n = 97) had significantly greater adjusted BMD decline than controls (n = 614) during the first 96 weeks of ART. Subsequently, the rate of BMD decline slowed in HIV-infected individuals but remained greater than the rate of decline in HIV-uninfected individuals at the lumbar spine but not at the hip. In HIV-infected individuals after 96 weeks, no HIV-or treatment-related characteristic was associated with BMD loss, but lower lean body mass was associated with greater BMD loss at both lumbar spine and hip.

Original language	English (US)
Pages (from-to)	607-611
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	214
Issue number	4
DOIs	https://doi.org/10.1093/infdis/jiw204
State	Published - Aug 15 2016

Keywords

Administration and dosage
Adverse effects
Anti-HIV agents
Bone density
Drug therapy/virology
HIV infections

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jiw204

Cite this

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title = "Long-term bone mineral density changes in antiretroviral-treated HIV-infected individuals",

abstract = "We compared adjusted bone mineral density (BMD) changes between human immunodeficiency virus (HIV)-infected individuals during the first approximately 7.5 years after antiretroviral therapy (ART) initiation and HIV-uninfected controls. HIV-infected individuals (n = 97) had significantly greater adjusted BMD decline than controls (n = 614) during the first 96 weeks of ART. Subsequently, the rate of BMD decline slowed in HIV-infected individuals but remained greater than the rate of decline in HIV-uninfected individuals at the lumbar spine but not at the hip. In HIV-infected individuals after 96 weeks, no HIV-or treatment-related characteristic was associated with BMD loss, but lower lean body mass was associated with greater BMD loss at both lumbar spine and hip.",

keywords = "Administration and dosage, Adverse effects, Anti-HIV agents, Bone density, Drug therapy/virology, HIV infections",

author = "Grant, {Philip M.} and Douglas Kitch and McComsey, {Grace A.} and Collier, {Ann C.} and Koletar, {Susan L.} and Erlandson, {Kristine M.} and Yin, {Michael T.} and Benedetta Bartali and Belinda Ha and Kathy Melbourne and Brown, {Todd T.}",

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doi = "10.1093/infdis/jiw204",

language = "English (US)",

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AU - Grant, Philip M.

AU - Kitch, Douglas

AU - McComsey, Grace A.

AU - Collier, Ann C.

AU - Koletar, Susan L.

AU - Erlandson, Kristine M.

AU - Yin, Michael T.

AU - Bartali, Benedetta

AU - Ha, Belinda

AU - Melbourne, Kathy

AU - Brown, Todd T.

N1 - Publisher Copyright: © The Author 2016.

PY - 2016/8/15

Y1 - 2016/8/15

N2 - We compared adjusted bone mineral density (BMD) changes between human immunodeficiency virus (HIV)-infected individuals during the first approximately 7.5 years after antiretroviral therapy (ART) initiation and HIV-uninfected controls. HIV-infected individuals (n = 97) had significantly greater adjusted BMD decline than controls (n = 614) during the first 96 weeks of ART. Subsequently, the rate of BMD decline slowed in HIV-infected individuals but remained greater than the rate of decline in HIV-uninfected individuals at the lumbar spine but not at the hip. In HIV-infected individuals after 96 weeks, no HIV-or treatment-related characteristic was associated with BMD loss, but lower lean body mass was associated with greater BMD loss at both lumbar spine and hip.

AB - We compared adjusted bone mineral density (BMD) changes between human immunodeficiency virus (HIV)-infected individuals during the first approximately 7.5 years after antiretroviral therapy (ART) initiation and HIV-uninfected controls. HIV-infected individuals (n = 97) had significantly greater adjusted BMD decline than controls (n = 614) during the first 96 weeks of ART. Subsequently, the rate of BMD decline slowed in HIV-infected individuals but remained greater than the rate of decline in HIV-uninfected individuals at the lumbar spine but not at the hip. In HIV-infected individuals after 96 weeks, no HIV-or treatment-related characteristic was associated with BMD loss, but lower lean body mass was associated with greater BMD loss at both lumbar spine and hip.

KW - Administration and dosage

KW - Adverse effects

KW - Anti-HIV agents

KW - Bone density

KW - Drug therapy/virology

KW - HIV infections

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ER -

Long-term bone mineral density changes in antiretroviral-treated HIV-infected individuals

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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