Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men

Huiming Zhang, Koji Tamakoshi, Hiroshi Yatsuya, Chiyoe Murata, Keiko Wada, Rei Otsuka, Nobue Nagasawa, Miyuki Ishikawa, Kaichiro Sugiura, Kunihiro Matsushita, Yoko Hori, Takaaki Kondo, Hideaki Toyoshima

Research output: Contribution to journalArticle

Abstract

Background: The relation between weight fluctuation and the risk of cardiovascular disease (CVD) is fairly consistent, although the physiologic basis for the relationship is uncertain. In the present study the association between long-term weight fluctuation and the development of metabolic syndrome (MS), a potent CVD risk factor, was investigated. Methods and Results: A cross-sectional study of 664 Japanese men aged 40-49 years was conducted. The root mean square error around the slope of weight on age (weight-RMSE) was calculated by a simple linear regression model, in which the subject's actual weights at ages 20, 25, 30 years and 5 years prior to the study, as well as current weight, were dependent variables against the subject's age as the independent variable. Weight-RMSE was significantly and positively associated with the prevalence of each MS components (high blood pressure, hypertriglyceridemia, low-high density lipoprotein-cholesterol, high fasting glucose, and obesity). Such associations, as well as clustering of the MS component together with RMSE increase, were apparent among subjects with body mass index (BMI) 2, although the prevalence of MS or its components was much higher among overweight subjects (BMI ≥25 kg/m 2). Conclusions: Development of MS possibly explains the risk of CVD not only in overweight or obese persons, but also in normal-weight persons with large weight fluctuation.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalCirculation Journal
Volume69
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

Fingerprint

Body Mass Index
Body Weight
Weights and Measures
Cardiovascular Diseases
Linear Models
Hypertriglyceridemia
LDL Cholesterol
HDL Cholesterol
Cluster Analysis
Fasting
Obesity
Cross-Sectional Studies
Hypertension
Glucose

Keywords

  • Cardiovascular disease risk factor
  • Metabolic syndrome
  • Weight fluctuation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men. / Zhang, Huiming; Tamakoshi, Koji; Yatsuya, Hiroshi; Murata, Chiyoe; Wada, Keiko; Otsuka, Rei; Nagasawa, Nobue; Ishikawa, Miyuki; Sugiura, Kaichiro; Matsushita, Kunihiro; Hori, Yoko; Kondo, Takaaki; Toyoshima, Hideaki.

In: Circulation Journal, Vol. 69, No. 1, 01.2005, p. 13-18.

Research output: Contribution to journalArticle

Zhang, H, Tamakoshi, K, Yatsuya, H, Murata, C, Wada, K, Otsuka, R, Nagasawa, N, Ishikawa, M, Sugiura, K, Matsushita, K, Hori, Y, Kondo, T & Toyoshima, H 2005, 'Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men', Circulation Journal, vol. 69, no. 1, pp. 13-18. https://doi.org/10.1253/circj.69.13
Zhang, Huiming ; Tamakoshi, Koji ; Yatsuya, Hiroshi ; Murata, Chiyoe ; Wada, Keiko ; Otsuka, Rei ; Nagasawa, Nobue ; Ishikawa, Miyuki ; Sugiura, Kaichiro ; Matsushita, Kunihiro ; Hori, Yoko ; Kondo, Takaaki ; Toyoshima, Hideaki. / Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men. In: Circulation Journal. 2005 ; Vol. 69, No. 1. pp. 13-18.
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