TY - GEN
T1 - Long-term assessment of post-cardiac-arrest neurological outcomes with somatosensory evoked potential in rats
AU - Kang, Xiaoxu
AU - Xiong, Wei
AU - Koenig, Matthew
AU - Puttgen, Hans Adrian
AU - Jia, Xiaofeng
AU - Geocadin, Romergryko
AU - Thakor, Nitish
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - Cardiac arrest (CA) can produce complex changes in somatosensory evoked potentials (SSEPs). Somatosensory evoked potentials (SSEPs) indicate the intactness of somatosensory pathways and are commonly used for brain function monitoring during surgeries. Multiresolution biorthogonal wavelet analysis was applied to SSEPs recorded during established CA experiments and post-CA long-term recovery periods in rats. Our results showed that during the first 4 hours after CA, the amplitudes of SSEP, defined here as the difference between the amplitudes of P23 and N20, decreased greatly while the inter-peak latencies between N20 and P23 increased greatly. In the long-term recovery period (within 72 hours), both the amplitudes of SSEPs and the interpeak latencies returned to the baseline. Our results suggest that the changes of SSEPs may represent the post-CA neurological injuries and recovery in the somatosensory afferent pathways. The results here lay ground work for establishing the relationship between SSEPs and post-CA neurological injuries and functional outcomes as well as deploying SSEP in clinical settings to monitor patients resuscitated from CA in the future.
AB - Cardiac arrest (CA) can produce complex changes in somatosensory evoked potentials (SSEPs). Somatosensory evoked potentials (SSEPs) indicate the intactness of somatosensory pathways and are commonly used for brain function monitoring during surgeries. Multiresolution biorthogonal wavelet analysis was applied to SSEPs recorded during established CA experiments and post-CA long-term recovery periods in rats. Our results showed that during the first 4 hours after CA, the amplitudes of SSEP, defined here as the difference between the amplitudes of P23 and N20, decreased greatly while the inter-peak latencies between N20 and P23 increased greatly. In the long-term recovery period (within 72 hours), both the amplitudes of SSEPs and the interpeak latencies returned to the baseline. Our results suggest that the changes of SSEPs may represent the post-CA neurological injuries and recovery in the somatosensory afferent pathways. The results here lay ground work for establishing the relationship between SSEPs and post-CA neurological injuries and functional outcomes as well as deploying SSEP in clinical settings to monitor patients resuscitated from CA in the future.
UR - http://www.scopus.com/inward/record.url?scp=77951012925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951012925&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2009.5334918
DO - 10.1109/IEMBS.2009.5334918
M3 - Conference contribution
C2 - 19965151
AN - SCOPUS:77951012925
SN - 9781424432967
T3 - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
SP - 2196
EP - 2199
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - IEEE Computer Society
T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Y2 - 2 September 2009 through 6 September 2009
ER -