Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding

Stephen J. Peroutka, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Antidepressants compete at several neurotransmitter receptor binding sites, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and β-adrenergic receptors. The decrease in the number ofreceptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.

Original languageEnglish (US)
Pages (from-to)88-90
Number of pages3
JournalScience
Volume210
Issue number4465
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • General

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