Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding

Stephen J. Peroutka, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Antidepressants compete at several neurotransmitter receptor binding sites, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and β-adrenergic receptors. The decrease in the number ofreceptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.

Original languageEnglish (US)
Pages (from-to)88-90
Number of pages3
JournalScience
Volume210
Issue number4465
StatePublished - 1980

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Spiperone
Serotonin Receptors
Antidepressive Agents
Neurotransmitter Receptor
Adrenergic Receptors
Binding Sites
Pharmaceutical Preparations

ASJC Scopus subject areas

  • General

Cite this

Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding. / Peroutka, Stephen J.; Snyder, Solomon H.

In: Science, Vol. 210, No. 4465, 1980, p. 88-90.

Research output: Contribution to journalArticle

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