Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding

Stephen J. Peroutka; Solomon H. Snyder

doi:10.1126/science.6251550

Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding

Stephen J. Peroutka, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

742 Scopus citations

Abstract

Antidepressants compete at several neurotransmitter receptor binding sites, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and β-adrenergic receptors. The decrease in the number ofreceptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.

Original language	English (US)
Pages (from-to)	88-90
Number of pages	3
Journal	Science
Volume	210
Issue number	4465
DOIs	https://doi.org/10.1126/science.6251550
State	Published - 1980

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title = "Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding",

abstract = "Antidepressants compete at several neurotransmitter receptor binding sites, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and β-adrenergic receptors. The decrease in the number ofreceptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.",

author = "Peroutka, {Stephen J.} and Snyder, {Solomon H.}",

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AB - Antidepressants compete at several neurotransmitter receptor binding sites, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and β-adrenergic receptors. The decrease in the number ofreceptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.

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Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding

Abstract

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