Long-latency reflex activity in squirrel monkeys with occlusion of the middle cerebral artery

Frederick Lenz, R. R. Tasker, W. G. Tatton, W. Halliday

Research output: Contribution to journalArticle

Abstract

The primate middle cerebral artery (MCA) preparation has been studied as an animal model of human spasticity resulting from stroke. MCA occlusion in 3 squirrel monkeys was accomplished through a transorbital approach and animals were evaluated by 'clinical' examinations and studies of EMG responses to torque motor imposed joint displacement. Animals were transiently hemiparetic but not spastic postoperatively, although all were found to have a large infarct in MCA territory on post-mortem examination. The electromyographic (EMG) response of biceps in normal animals to torque motor imposed elbow extension consisted of both early (M1) and late (M2) components (Tatton et al. 1975). These components were unchanged following MCA occlusion. The EMG response to metacarpophalangeal joint extension in finger flexors of normal animals consisted solely of a long-latency (M2) component (Lenz et al. 1983a). Following MCA occlusion the M2 component in this muscle was decreased or absent, but a short-latency (M1) component appeared.

Original languageEnglish (US)
Pages (from-to)238-246
Number of pages9
JournalElectroencephalography and Clinical Neurophysiology
Volume67
Issue number3
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Saimiri
Middle Cerebral Artery Infarction
Reflex
Middle Cerebral Artery
Torque
Metacarpophalangeal Joint
Muscle Spasticity
Elbow
Primates
Fingers
Autopsy
Animal Models
Joints
Stroke
Muscles

Keywords

  • Monkey
  • Reflexes
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Long-latency reflex activity in squirrel monkeys with occlusion of the middle cerebral artery. / Lenz, Frederick; Tasker, R. R.; Tatton, W. G.; Halliday, W.

In: Electroencephalography and Clinical Neurophysiology, Vol. 67, No. 3, 1987, p. 238-246.

Research output: Contribution to journalArticle

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