Long-lasting increases in intrinsic excitability triggered by inhibition

Alexandra B. Nelson, Claudia M. Krispel, Chris Sekirnjak, Sascha Du Lac

Research output: Contribution to journalArticlepeer-review


Although experience-dependent changes in neural circuits are commonly assumed to be mediated by synaptic plasticity, modifications of intrinsic excitability may serve as a complementary mechanism. In whole-cell recordings from spontaneously firing vestibular nucleus neurons, brief periods of inhibitory synaptic stimulation or direct membrane hyperpolarization triggered long-lasting increases in spontaneous firing rates and firing responses to intracellular depolarization. These increases in excitability, termed firing rate potentiation, were induced by decreases in intracellular calcium and expressed as reductions in the sensitivity to the BK-type calcium-activated potassium channel blocker iberiotoxin. Firing rate potentiation is a novel form of cellular plasticity that could contribute to motor learning in the vestibulo-ocular reflex.

Original languageEnglish (US)
Pages (from-to)609-620
Number of pages12
Issue number3
StatePublished - Oct 30 2003
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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