TY - JOUR
T1 - Long interspersed element-1 protein expression is a hallmark of many human cancers
AU - Rodić, Nemanja
AU - Sharma, Reema
AU - Sharma, Rajni
AU - Zampella, John
AU - Dai, Lixin
AU - Taylor, Martin S.
AU - Hruban, Ralph H.
AU - Iacobuzio-Donahue, Christine A.
AU - Maitra, Anirban
AU - Torbenson, Michael S.
AU - Goggins, Michael
AU - Shih, Ie Ming
AU - Duffield, Amy S.
AU - Montgomery, Elizabeth A.
AU - Gabrielson, Edward
AU - Netto, George J.
AU - Lotan, Tamara L.
AU - De Marzo, Angelo M.
AU - Westra, William
AU - Binder, Zev A.
AU - Orr, Brent A.
AU - Gallia, Gary L.
AU - Eberhart, Charles G.
AU - Boeke, Jef D.
AU - Harris, Chris R.
AU - Burns, Kathleen H.
PY - 2014/5
Y1 - 2014/5
N2 - Cancers comprise a heterogeneous group of human diseases. Unifying characteristics include unchecked abilities of tumor cells to proliferate and spread anatomically, and the presence of clonal advantageous genetic changes. However, universal and highly specific tumor markers are unknown. Herein, we report widespread long interspersed element-1 (LINE-1) repeat expression in human cancers. We show that nearly half of all human cancers are immunoreactive for a LINE-1-encoded protein. LINE-1 protein expression is a common feature of many types of high-grade malignant cancers, is rarely detected in early stages of tumorigenesis, and is absent from normal somatic tissues. Studies have shown that LINE-1 contributes to genetic changes in cancers, with somatic LINE-1 insertions seen in selected types of human cancers, particularly colon cancer. We sought to correlate this observation with expression of the LINE-1-encoded protein, open reading frame 1 protein, and found that LINE-1 open reading frame 1 protein is a surprisingly broad, yet highly tumor-specific, antigen.
AB - Cancers comprise a heterogeneous group of human diseases. Unifying characteristics include unchecked abilities of tumor cells to proliferate and spread anatomically, and the presence of clonal advantageous genetic changes. However, universal and highly specific tumor markers are unknown. Herein, we report widespread long interspersed element-1 (LINE-1) repeat expression in human cancers. We show that nearly half of all human cancers are immunoreactive for a LINE-1-encoded protein. LINE-1 protein expression is a common feature of many types of high-grade malignant cancers, is rarely detected in early stages of tumorigenesis, and is absent from normal somatic tissues. Studies have shown that LINE-1 contributes to genetic changes in cancers, with somatic LINE-1 insertions seen in selected types of human cancers, particularly colon cancer. We sought to correlate this observation with expression of the LINE-1-encoded protein, open reading frame 1 protein, and found that LINE-1 open reading frame 1 protein is a surprisingly broad, yet highly tumor-specific, antigen.
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U2 - 10.1016/j.ajpath.2014.01.007
DO - 10.1016/j.ajpath.2014.01.007
M3 - Article
C2 - 24607009
AN - SCOPUS:84899548825
SN - 0002-9440
VL - 184
SP - 1280
EP - 1286
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 5
ER -