TY - JOUR
T1 - Long-Distance Control of Synapse Assembly by Target-Derived NGF
AU - Sharma, Nikhil
AU - Deppmann, Christopher D.
AU - Harrington, Anthony W.
AU - St. Hillaire, Coryse
AU - Chen, Zhe Yu
AU - Lee, Francis S.
AU - Ginty, David D.
PY - 2010/8
Y1 - 2010/8
N2 - We report a role for long-distance retrograde neurotrophin signaling in the establishment of synapses in the sympathetic nervous system. Target-derived NGF is both necessary and sufficient for formation of postsynaptic specializations on dendrites of sympathetic neurons. This, in turn, is a prerequisite for formation of presynaptic specializations, but not preganglionic axonal ingrowth from the spinal cord into sympathetic ganglia. We also find that NGF-TrkA signaling endosomes travel from distal axons to cell bodies and dendrites where they promote PSD clustering. Furthermore, the p75 neurotrophin receptor restricts PSD formation, suggesting an important role for antagonistic NGF-TrkA and p75 signaling pathways during retrograde control of synapse establishment. Thus, in addition to defining the appropriate number of sympathetic neurons that survive the period of developmental cell death, target-derived NGF also exerts control over the degree of connectivity between the spinal cord and sympathetic ganglia through retrograde control of synapse assembly. Video Abstract:
AB - We report a role for long-distance retrograde neurotrophin signaling in the establishment of synapses in the sympathetic nervous system. Target-derived NGF is both necessary and sufficient for formation of postsynaptic specializations on dendrites of sympathetic neurons. This, in turn, is a prerequisite for formation of presynaptic specializations, but not preganglionic axonal ingrowth from the spinal cord into sympathetic ganglia. We also find that NGF-TrkA signaling endosomes travel from distal axons to cell bodies and dendrites where they promote PSD clustering. Furthermore, the p75 neurotrophin receptor restricts PSD formation, suggesting an important role for antagonistic NGF-TrkA and p75 signaling pathways during retrograde control of synapse establishment. Thus, in addition to defining the appropriate number of sympathetic neurons that survive the period of developmental cell death, target-derived NGF also exerts control over the degree of connectivity between the spinal cord and sympathetic ganglia through retrograde control of synapse assembly. Video Abstract:
KW - Cellbio
KW - Devbio
KW - Molneruo
UR - http://www.scopus.com/inward/record.url?scp=77955434568&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955434568&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2010.07.018
DO - 10.1016/j.neuron.2010.07.018
M3 - Article
C2 - 20696380
AN - SCOPUS:77955434568
SN - 0896-6273
VL - 67
SP - 422
EP - 434
JO - Neuron
JF - Neuron
IS - 3
ER -