Long-Distance Control of Synapse Assembly by Target-Derived NGF

Nikhil Sharma, Christopher D. Deppmann, Anthony W. Harrington, Coryse St. Hillaire, Zhe Yu Chen, Francis S. Lee, David D. Ginty

Research output: Contribution to journalArticle

Abstract

We report a role for long-distance retrograde neurotrophin signaling in the establishment of synapses in the sympathetic nervous system. Target-derived NGF is both necessary and sufficient for formation of postsynaptic specializations on dendrites of sympathetic neurons. This, in turn, is a prerequisite for formation of presynaptic specializations, but not preganglionic axonal ingrowth from the spinal cord into sympathetic ganglia. We also find that NGF-TrkA signaling endosomes travel from distal axons to cell bodies and dendrites where they promote PSD clustering. Furthermore, the p75 neurotrophin receptor restricts PSD formation, suggesting an important role for antagonistic NGF-TrkA and p75 signaling pathways during retrograde control of synapse establishment. Thus, in addition to defining the appropriate number of sympathetic neurons that survive the period of developmental cell death, target-derived NGF also exerts control over the degree of connectivity between the spinal cord and sympathetic ganglia through retrograde control of synapse assembly. Video Abstract:

Original languageEnglish (US)
Pages (from-to)422-434
Number of pages13
JournalNeuron
Volume67
Issue number3
DOIs
StatePublished - Aug 2010

Fingerprint

Nerve Growth Factor
Synapses
Sympathetic Ganglia
Dendrites
Spinal Cord
Neurons
Nerve Growth Factor Receptor
Endosomes
Sympathetic Nervous System
Nerve Growth Factors
Spinal Ganglia
Cluster Analysis
Axons
Cell Death

Keywords

  • Cellbio
  • Devbio
  • Molneruo

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sharma, N., Deppmann, C. D., Harrington, A. W., St. Hillaire, C., Chen, Z. Y., Lee, F. S., & Ginty, D. D. (2010). Long-Distance Control of Synapse Assembly by Target-Derived NGF. Neuron, 67(3), 422-434. https://doi.org/10.1016/j.neuron.2010.07.018

Long-Distance Control of Synapse Assembly by Target-Derived NGF. / Sharma, Nikhil; Deppmann, Christopher D.; Harrington, Anthony W.; St. Hillaire, Coryse; Chen, Zhe Yu; Lee, Francis S.; Ginty, David D.

In: Neuron, Vol. 67, No. 3, 08.2010, p. 422-434.

Research output: Contribution to journalArticle

Sharma, N, Deppmann, CD, Harrington, AW, St. Hillaire, C, Chen, ZY, Lee, FS & Ginty, DD 2010, 'Long-Distance Control of Synapse Assembly by Target-Derived NGF', Neuron, vol. 67, no. 3, pp. 422-434. https://doi.org/10.1016/j.neuron.2010.07.018
Sharma N, Deppmann CD, Harrington AW, St. Hillaire C, Chen ZY, Lee FS et al. Long-Distance Control of Synapse Assembly by Target-Derived NGF. Neuron. 2010 Aug;67(3):422-434. https://doi.org/10.1016/j.neuron.2010.07.018
Sharma, Nikhil ; Deppmann, Christopher D. ; Harrington, Anthony W. ; St. Hillaire, Coryse ; Chen, Zhe Yu ; Lee, Francis S. ; Ginty, David D. / Long-Distance Control of Synapse Assembly by Target-Derived NGF. In: Neuron. 2010 ; Vol. 67, No. 3. pp. 422-434.
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