Locally invasive dermal squamomelanocytic tumor with matrical differentiation: A peculiar case with review of the literature

Nemanja Rodić, Janis M. Taube, Paul Manson, Manisha Patel, James W. Patterson, Gulsun Erdag

Research output: Contribution to journalReview article

Abstract

Dermal-based combined squamous and melanocytic neoplasms are emerging clinicopathologic entities that tend to appear on sun-exposed areas of elderly patients. The biologic behavior of such cutaneous neoplasms remains uncertain because of their rarity. Histopathologic differential includes the following diagnostic entities: (1) dermal squamomelanocytic tumor, (2) melanocytic matricoma, and (3) rare histologic variant of pilomatrical carcinoma, the so-called pilomatrical carcinoma with intralesional melanocytes. Herein, we present a novel case of locally invasive dermal squamomelanocytic tumor. A 72-year-old man presented with a pigmented papule on nasal ala that was clinically concerning for basal cell carcinoma. Histopathologic evaluation demonstrated atypical melanocytic cells architecturally and intimately intermixed with single units and clusters of atypical squamous cells. Most notable feature of this case is focal matrical differentiation and locally invasive tumor growth, characterized by multifocal perineural invasion.

Original languageEnglish (US)
Pages (from-to)e72-e76
JournalAmerican Journal of Dermatopathology
Volume35
Issue number4
DOIs
StatePublished - Jun 18 2013

Keywords

  • dermal squamomelanocytic tumormelanocytic matricoma
  • perineural invasion
  • pilomatrical carcinoma with intralesional melanocytes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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