Localized one-dimensional single voxel magnetic resonance spectroscopy without J coupling modulations

Yanqin Lin, Liangjie Lin, Zhiliang Wei, Jianhui Zhong, Zhong Chen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Purpose: To acquire single voxel localized one-dimensional 1H magnetic resonance spectroscopy (MRS) without J coupling modulations, free from amplitude and phase distortions. Methods: A pulse sequence, named PRESSIR, is developed for volume localized MRS without J modulations at arbitrary echo time (TE). The J coupling evolution is suppressed by the J-refocused module that uses a 90° pulse at the midpoint of a double spin echo. Results: The localization performance of the PRESSIR sequence was tested with a two-compartment phantom. The proposed sequence shows similar voxel localization accuracy as PRESS. Both PRESSIR and PRESS sequences were performed on MRS brain phantom and pig brain tissue. PRESS spectra suffer from amplitude and phase distortions due to J modulations, especially under moderate and long TEs, while PRESSIR spectra are almost free from distortions. Conclusion: The PRESSIR sequence proposed herein enables the acquisition of single voxel in-phase MRS within a single scan. It allows an enhanced signal intensity of J coupling metabolites and reducing undesired broad resonances with short T2s while suppressing J modulations. Moreover, it provides an approach for direct measurement of nonoverlapping J coupling peaks and of transverse relaxation times T2s. Magn Reson Med 76:1661–1667, 2016.

Original languageEnglish (US)
Pages (from-to)1661-1667
Number of pages7
JournalMagnetic resonance in medicine
Issue number6
StatePublished - Dec 1 2016
Externally publishedYes


  • J coupling modulation
  • in-phase
  • localized magnetic resonance spectroscopy (MRS)
  • phase distortion
  • single voxel

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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