Localized and lateralized cerebral glucose metabolism associated with eye movements during REM sleep and wakefulness: A positron emission tomography (PET) study

Charles Chong-Hwa Hong, J. C. Gillin, B. M. Dow, J. Wu, M. S. Buchsbaum

Research output: Contribution to journalArticle

Abstract

In order to study the neural substrate for eye movements during rapid eye movement (REM) sleep, we analyzed the positron emission tomography (18Fluorodeoxyglucose positron emission tomography) scan data obtained from normal subjects. Eye movement data were available on nine subjects studied during nighttime REM sleep and six control subjects studied during waking as they periodically moved their eyes. The number of eye movements during REM sleep was positively correlated with glucose metabolic rate in the areas corresponding to (a) the saccadic eye movement system (frontal eye field and dorsolateral prefrontal cortex, statistically significant only on the right side), (b) the midline attentional system (cingulate and medial frontal cortex, precuneus) and (c) the parietal visual spatial attentional system (bilateral superior parietal lobules, right inferior parietal lobule); and negatively correlated with relative metabolic rate in the left inferior parietal lobule. Positive correlations between waking eye movements and metabolic rate were observed in the same areas except inferior parietal lobule. Our results show that the same cortical areas are involved in eye movements in both REM sleep and wakefulness and suggest that REM sleep eye movements are saccadic scans of targets in the dream scene. Our data also suggest right hemispheric specialization in saccadic eye movement control and reciprocal inhibition in the contralateral homologous area during higher conical functioning.

Original languageEnglish (US)
Pages (from-to)570-580
Number of pages11
JournalSleep
Volume18
Issue number7
StatePublished - 1995
Externally publishedYes

Fingerprint

Parietal Lobe
Wakefulness
REM Sleep
Eye Movements
Positron-Emission Tomography
Sleep
Saccades
Glucose
Frontal Lobe
Cerebral Dominance
Prefrontal Cortex

Keywords

  • Attention
  • Cerebral laterality
  • Cortex
  • Dream
  • Fluorodeoxyglucose
  • REM density
  • Saccades
  • Visual imagery

ASJC Scopus subject areas

  • Physiology

Cite this

Localized and lateralized cerebral glucose metabolism associated with eye movements during REM sleep and wakefulness : A positron emission tomography (PET) study. / Hong, Charles Chong-Hwa; Gillin, J. C.; Dow, B. M.; Wu, J.; Buchsbaum, M. S.

In: Sleep, Vol. 18, No. 7, 1995, p. 570-580.

Research output: Contribution to journalArticle

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abstract = "In order to study the neural substrate for eye movements during rapid eye movement (REM) sleep, we analyzed the positron emission tomography (18Fluorodeoxyglucose positron emission tomography) scan data obtained from normal subjects. Eye movement data were available on nine subjects studied during nighttime REM sleep and six control subjects studied during waking as they periodically moved their eyes. The number of eye movements during REM sleep was positively correlated with glucose metabolic rate in the areas corresponding to (a) the saccadic eye movement system (frontal eye field and dorsolateral prefrontal cortex, statistically significant only on the right side), (b) the midline attentional system (cingulate and medial frontal cortex, precuneus) and (c) the parietal visual spatial attentional system (bilateral superior parietal lobules, right inferior parietal lobule); and negatively correlated with relative metabolic rate in the left inferior parietal lobule. Positive correlations between waking eye movements and metabolic rate were observed in the same areas except inferior parietal lobule. Our results show that the same cortical areas are involved in eye movements in both REM sleep and wakefulness and suggest that REM sleep eye movements are saccadic scans of targets in the dream scene. Our data also suggest right hemispheric specialization in saccadic eye movement control and reciprocal inhibition in the contralateral homologous area during higher conical functioning.",
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T2 - A positron emission tomography (PET) study

AU - Hong, Charles Chong-Hwa

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AU - Dow, B. M.

AU - Wu, J.

AU - Buchsbaum, M. S.

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