Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13

C. E. Carow, E. Kim, A. L. Hawkins, H. D. Webb, C. A. Griffin, E. W. Jabs, C. I. Civin, Donald Small

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34+ human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12→q13.

Original languageEnglish (US)
Pages (from-to)255-257
Number of pages3
JournalCytogenetic and Genome Research
Volume70
Issue number3-4
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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