Localization of the gene encoding RκB (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25

Barbara S. Adams, Kwanyee Leung, Paul S. Meltzer, Kathy A. Lewis, Caryn Wagner-McPherson, Glen A. Evans, Gary J. Nabel

Research output: Contribution to journalArticle

Abstract

Although NF (nuclear factor)-κB binds in vitro to several of the κB regulatory elements found in cellular and viral genes, another DNA binding protein, RκB, also binds to a related variant of the κB site that regulates interleukin-2 receptor α-chain gene expression, a critical event in T cell activation. Southern blot analysis of a human-mouse somatic cell hybrid panel and in situ hybridization using a fluorescent genomic RκB probe have allowed assignment of the RκB gene (NFRKB) to 11q24-q25. The NFRKB locus is in close proximity to the chromosomal breakpoint implicated in Ewing sarcoma, but it does not appear to span this region. Nonetheless, NFRKB may be particularly useful as the most telomeric marker thus far assigned to 11q.

Original languageEnglish (US)
Pages (from-to)270-274
Number of pages5
JournalGenomics
Volume14
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

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Ewing's Sarcoma
Viral Genes
Hybrid Cells
Interleukin-2 Receptors
DNA-Binding Proteins
Southern Blotting
In Situ Hybridization
Chromosomes
T-Lymphocytes
Gene Expression
Genes
In Vitro Techniques

ASJC Scopus subject areas

  • Genetics

Cite this

Adams, B. S., Leung, K., Meltzer, P. S., Lewis, K. A., Wagner-McPherson, C., Evans, G. A., & Nabel, G. J. (1992). Localization of the gene encoding RκB (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25. Genomics, 14(2), 270-274. https://doi.org/10.1016/S0888-7543(05)80216-2

Localization of the gene encoding RκB (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25. / Adams, Barbara S.; Leung, Kwanyee; Meltzer, Paul S.; Lewis, Kathy A.; Wagner-McPherson, Caryn; Evans, Glen A.; Nabel, Gary J.

In: Genomics, Vol. 14, No. 2, 1992, p. 270-274.

Research output: Contribution to journalArticle

Adams, BS, Leung, K, Meltzer, PS, Lewis, KA, Wagner-McPherson, C, Evans, GA & Nabel, GJ 1992, 'Localization of the gene encoding RκB (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25', Genomics, vol. 14, no. 2, pp. 270-274. https://doi.org/10.1016/S0888-7543(05)80216-2
Adams, Barbara S. ; Leung, Kwanyee ; Meltzer, Paul S. ; Lewis, Kathy A. ; Wagner-McPherson, Caryn ; Evans, Glen A. ; Nabel, Gary J. / Localization of the gene encoding RκB (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25. In: Genomics. 1992 ; Vol. 14, No. 2. pp. 270-274.
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