Localization of G6PD and HPRT to different arms of the X chromosome of the North American marsupial (Didelphis virginiana) by in situ hybridization and delection mapping: Evolutionary significance

Daniel J. Driscoll, Barbara R. Migeon

Research output: Contribution to journalArticlepeer-review

Abstract

We have mapped HPRT and G6PD loci on the X chromosome in the American opossum, Didelphis virginiana, by in situ hybridization to cells derived from two females by using genomic opossum DNA as probes. The localizations (G6PD to Xp13 and HPRT to Xq21), indicating that the two genes are separated by the centromere, were confirmed by results of hybridization to X chromosomes with deletions that include the HPRT locus and opossum-mouse cell hybrids containing the relevant fragment of the opossum X chromosome.

Original languageEnglish (US)
Pages (from-to)308-314
Number of pages7
JournalGenomics
Volume3
Issue number4
DOIs
StatePublished - Nov 1988

ASJC Scopus subject areas

  • Genetics

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