Localization of alpha-fetoprotein and human chorionic gonadotropin to specific histologic types of nonseminomatous testicular cancer

Jackson E. Fowler, Isabell Sesterhenn, Ray Stutzman, F. Kash Mostofi

Research output: Contribution to journalArticle

Abstract

We used an indirect immunoperoxidase technique to localize alpha fetoprotein (AFP) and human chorionic gonadotropin (HCG) to specific histologic types of testicular germ cell cancers. Among 20 nonseminomatous tumors studied, yolk sac tumor reacted for AFP in 13 of 15 cases, teratoma in 3 of 11 cases, and embryonal carcinoma in 3 of 14 cases. Syncytiotrophoblasts alone reacted for HCG in 14 of 15 cases, and syncytiotrophoblasts associated with choriocarcinoma reacted for HCG in 2 of 2 cases. There was a close correlation between the tissue demonstration of AFP and HCG and elevated serum levels of AFP and HCG, respectively. We conclude that in nonseminomatous testicular cancer yolk sac tumor is the primary site of synthesis of AFP, and syncytiotrophoblasts are the only site of synthesis of HCG.

Original languageEnglish (US)
Pages (from-to)649-654
Number of pages6
JournalUrology
Volume22
Issue number6
DOIs
StatePublished - 1983
Externally publishedYes

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Alpha Subunit Glycoprotein Hormones
Testicular Neoplasms
alpha-Fetoproteins
Chorionic Gonadotropin
Trophoblasts
Endodermal Sinus Tumor
Embryonal Carcinoma
Choriocarcinoma
Germ Cell and Embryonal Neoplasms
Teratoma
Immunoenzyme Techniques
Serum

ASJC Scopus subject areas

  • Urology

Cite this

Localization of alpha-fetoprotein and human chorionic gonadotropin to specific histologic types of nonseminomatous testicular cancer. / Fowler, Jackson E.; Sesterhenn, Isabell; Stutzman, Ray; Mostofi, F. Kash.

In: Urology, Vol. 22, No. 6, 1983, p. 649-654.

Research output: Contribution to journalArticle

Fowler, Jackson E. ; Sesterhenn, Isabell ; Stutzman, Ray ; Mostofi, F. Kash. / Localization of alpha-fetoprotein and human chorionic gonadotropin to specific histologic types of nonseminomatous testicular cancer. In: Urology. 1983 ; Vol. 22, No. 6. pp. 649-654.
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