Localization of a hereditary neuroblastoma predisposition gene to 16p12-p13

Matthew J. Weiss, Chun Guo, Suzanne Shusterman, George Hii, Tamar L. Mirensky, Peter S. White, Michael D. Hogarty, Timothy R. Rebbeck, Dawn Teare, Margrit Urbanek, Garrett M. Brodeur, John M. Maris

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background. Hereditary predisposition to develop neuroblastoma segregates as an autosomal dominant Mendelian trait. Procedure. We have performed linkage analysis on 10 families with neuroblastoma to localize a hereditary neuroblastoma predisposition gene (HNB1). Results. A single genomic interval at chromosome bands 16p12-p13 was consistent with linkage (lod = 3.46), and identification of informative recombinants defined a 25.9-cM critical region between D16S748 and D16S3068. Loss of heterozygosity was identified in 5/12 familial (42%) and 55/259 nonfamilial (21%) neuroblastomas at multiple 16p polymorphic loci. A 12.8-cM smallest region of overlap of deletions was identified within the interval defined by linkage analysis (tel-D16S764-D16S412-cen). Conclusions. Taken together, these data suggest that HNB1 is located at 16p12-p13 and that inactivation of this gene may contribute to the pathogenesis of nonfamilial neuroblastomas. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)526-530
Number of pages5
JournalMedical and Pediatric Oncology
Issue number6
StatePublished - 2000
Externally publishedYes


  • Chromosome, human, pair 16
  • Genes, suppressor, tumor
  • Genetics
  • Linkage
  • Neuroblastoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research


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