Local scattering property scales flow speed estimation in laser speckle contrast imaging

Peng Miao, Zhen Chao, Shihan Feng, Hang Yu, Yuanyuan Ji, Nan Li, Nitish V Thakor

Research output: Contribution to journalArticle

Abstract

Laser speckle contrast imaging (LSCI) has been widely used in in vivo blood flow imaging. However, the effect of local scattering property (scattering coefficient s) on blood flow speed estimation has not been well investigated. In this study, such an effect was quantified and involved in relation between speckle autocorrelation time τ c and flow speed v based on simulation flow experiments. For in vivo blood flow imaging, an improved estimation strategy was developed to eliminate the estimation bias due to the inhomogeneous distribution of the scattering property. Compared to traditional LSCI, a new estimation method significantly suppressed the imaging noise and improves the imaging contrast of vasculatures. Furthermore, the new method successfully captured the blood flow changes and vascular constriction patterns in rats' cerebral cortex from normothermia to mild and moderate hypothermia.

Original languageEnglish (US)
Article number075601
JournalLaser Physics Letters
Volume12
Issue number7
DOIs
StatePublished - Jun 1 2015

Fingerprint

blood flow
Speckle
Scattering
Imaging techniques
Lasers
Blood
scattering
lasers
hypothermia
cerebral cortex
scattering coefficients
Hypothermia
rats
autocorrelation
constrictions
Flow simulation
Autocorrelation
Rats
simulation
Experiments

Keywords

  • cerebral blood flow
  • hypothermia
  • laser speckle contrast imaging
  • speckle autocorrelation time

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)
  • Instrumentation

Cite this

Local scattering property scales flow speed estimation in laser speckle contrast imaging. / Miao, Peng; Chao, Zhen; Feng, Shihan; Yu, Hang; Ji, Yuanyuan; Li, Nan; Thakor, Nitish V.

In: Laser Physics Letters, Vol. 12, No. 7, 075601, 01.06.2015.

Research output: Contribution to journalArticle

Miao, Peng ; Chao, Zhen ; Feng, Shihan ; Yu, Hang ; Ji, Yuanyuan ; Li, Nan ; Thakor, Nitish V. / Local scattering property scales flow speed estimation in laser speckle contrast imaging. In: Laser Physics Letters. 2015 ; Vol. 12, No. 7.
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