Abstract
Purpose: The purpose of this study was to perform a detailed clinical pathological analysis of breast relapses in patients treated with conservative surgery and radiation therapy in an effort to classify those relapses as true local recurrences or second primary tumors, and to assess the prognostic and therapeutic implications of such a classification system. Methods and Materials: Of 990 patients treated with conservative surgery and radiation therapy at our facilities prior to December 1987, 82 patients have experienced a relapse in the conservatively treated breast as the primary site of failure. Patients were classified as having new primary tumors if they fulfilled any one of the following criteria: a) breast relapse occurring at a site distinctly removed from the original tumor; b) histology of the breast relapse compared with the original tumor consistent with a new primary; or c) DNA flow cytometry converting from an aneuploid primary to a diploid relapse. Results: As of 2/92, with a median follow-up of 5.4 years from the time of breast relapse, the overall 5-year survival rate following breast relapse was 55%. Forty-seven patients were classified as true recurrences and 33 patients were classified as new primaries. Patients classified as true recurrences had a shorter median time to breast relapse than patients classified as new primaries (3.16 years vs.5.42 years, p
Original language | English (US) |
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Pages (from-to) | 575-583 |
Number of pages | 9 |
Journal | International Journal of Radiation Oncology, Biology, Physics |
Volume | 27 |
Issue number | 3 |
DOIs | |
State | Published - Oct 20 1993 |
Externally published | Yes |
Keywords
- Conservative surgery and radiation therapy
- Genetic fingerprinting
- Local recurrence
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Radiation