Local recurrence in malignant melanoma: Long-term results of the multiinstitutional randomized surgical trial

Constantine P. Karakousis, Charles M. Balch, Marshall M. Urist, Merrick M. Ross, Thomas J. Smith, Alfred A. Bartolucci

Research output: Contribution to journalArticle

Abstract

Background: In the past, radical margins of excision were prescribed for cutaneous melanoma based on preconceived notions rather than on hard clinical evidence. Methods: In a prospective study of 742 patients with intermediate-thickness melanoma (1-4 mm), 470 patients with trunk or proximal extremity lesions were randomized into a 2-or 4-cm margin. Patients with distal extremity or head and neck lesions (n = 272) received uniformly a 2-cm margin. Results: The overall rate of local recurrence was 3.8%. This rate in the randomized portion (n = 470) was 2.1% for the 2-cm margin and 2.6% for the 4-cm margin (p = 0.72). A progressive increase in local recurrence rates was observed with thickness: 2.3% for lesions 1.0-2.0 mm, 4.2% for those 2.01-3.0 mm, and 11.7% for those 3.01-4.0 mm thick (p = 0.001). Local recurrence occurred in 1.5% of those without ulceration and in 10.6% of those with ulceration of the primary lesion (p = 0.001). The local recurrence rate was not significantly affected by the margin of resection even among the thicker or ulcerated lesions. It also was not affected significantly by the method of closure of the primary site or management of the regional nodes, or the age or gender of the patients. Conclusions: A 2-cm margin is as effective as a 4-cm margin in local control and survival of intermediate-thickness melanomas. The local recurrence rate is significantly affected by the thickness of the primary lesion and the presence or not of ulceration.

Original languageEnglish (US)
Pages (from-to)446-452
Number of pages7
JournalAnnals of Surgical Oncology
Volume3
Issue number5
StatePublished - 1996
Externally publishedYes

Fingerprint

Melanoma
Recurrence
Extremities
varespladib methyl
Neck
Head
Prospective Studies
Skin
Survival
Margins of Excision

Keywords

  • Local recurrence
  • Melanoma
  • Resection margins

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Karakousis, C. P., Balch, C. M., Urist, M. M., Ross, M. M., Smith, T. J., & Bartolucci, A. A. (1996). Local recurrence in malignant melanoma: Long-term results of the multiinstitutional randomized surgical trial. Annals of Surgical Oncology, 3(5), 446-452.

Local recurrence in malignant melanoma : Long-term results of the multiinstitutional randomized surgical trial. / Karakousis, Constantine P.; Balch, Charles M.; Urist, Marshall M.; Ross, Merrick M.; Smith, Thomas J.; Bartolucci, Alfred A.

In: Annals of Surgical Oncology, Vol. 3, No. 5, 1996, p. 446-452.

Research output: Contribution to journalArticle

Karakousis, CP, Balch, CM, Urist, MM, Ross, MM, Smith, TJ & Bartolucci, AA 1996, 'Local recurrence in malignant melanoma: Long-term results of the multiinstitutional randomized surgical trial', Annals of Surgical Oncology, vol. 3, no. 5, pp. 446-452.
Karakousis, Constantine P. ; Balch, Charles M. ; Urist, Marshall M. ; Ross, Merrick M. ; Smith, Thomas J. ; Bartolucci, Alfred A. / Local recurrence in malignant melanoma : Long-term results of the multiinstitutional randomized surgical trial. In: Annals of Surgical Oncology. 1996 ; Vol. 3, No. 5. pp. 446-452.
@article{859a05cd02c94d3491801d02fa9f29a8,
title = "Local recurrence in malignant melanoma: Long-term results of the multiinstitutional randomized surgical trial",
abstract = "Background: In the past, radical margins of excision were prescribed for cutaneous melanoma based on preconceived notions rather than on hard clinical evidence. Methods: In a prospective study of 742 patients with intermediate-thickness melanoma (1-4 mm), 470 patients with trunk or proximal extremity lesions were randomized into a 2-or 4-cm margin. Patients with distal extremity or head and neck lesions (n = 272) received uniformly a 2-cm margin. Results: The overall rate of local recurrence was 3.8{\%}. This rate in the randomized portion (n = 470) was 2.1{\%} for the 2-cm margin and 2.6{\%} for the 4-cm margin (p = 0.72). A progressive increase in local recurrence rates was observed with thickness: 2.3{\%} for lesions 1.0-2.0 mm, 4.2{\%} for those 2.01-3.0 mm, and 11.7{\%} for those 3.01-4.0 mm thick (p = 0.001). Local recurrence occurred in 1.5{\%} of those without ulceration and in 10.6{\%} of those with ulceration of the primary lesion (p = 0.001). The local recurrence rate was not significantly affected by the margin of resection even among the thicker or ulcerated lesions. It also was not affected significantly by the method of closure of the primary site or management of the regional nodes, or the age or gender of the patients. Conclusions: A 2-cm margin is as effective as a 4-cm margin in local control and survival of intermediate-thickness melanomas. The local recurrence rate is significantly affected by the thickness of the primary lesion and the presence or not of ulceration.",
keywords = "Local recurrence, Melanoma, Resection margins",
author = "Karakousis, {Constantine P.} and Balch, {Charles M.} and Urist, {Marshall M.} and Ross, {Merrick M.} and Smith, {Thomas J.} and Bartolucci, {Alfred A.}",
year = "1996",
language = "English (US)",
volume = "3",
pages = "446--452",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "5",

}

TY - JOUR

T1 - Local recurrence in malignant melanoma

T2 - Long-term results of the multiinstitutional randomized surgical trial

AU - Karakousis, Constantine P.

AU - Balch, Charles M.

AU - Urist, Marshall M.

AU - Ross, Merrick M.

AU - Smith, Thomas J.

AU - Bartolucci, Alfred A.

PY - 1996

Y1 - 1996

N2 - Background: In the past, radical margins of excision were prescribed for cutaneous melanoma based on preconceived notions rather than on hard clinical evidence. Methods: In a prospective study of 742 patients with intermediate-thickness melanoma (1-4 mm), 470 patients with trunk or proximal extremity lesions were randomized into a 2-or 4-cm margin. Patients with distal extremity or head and neck lesions (n = 272) received uniformly a 2-cm margin. Results: The overall rate of local recurrence was 3.8%. This rate in the randomized portion (n = 470) was 2.1% for the 2-cm margin and 2.6% for the 4-cm margin (p = 0.72). A progressive increase in local recurrence rates was observed with thickness: 2.3% for lesions 1.0-2.0 mm, 4.2% for those 2.01-3.0 mm, and 11.7% for those 3.01-4.0 mm thick (p = 0.001). Local recurrence occurred in 1.5% of those without ulceration and in 10.6% of those with ulceration of the primary lesion (p = 0.001). The local recurrence rate was not significantly affected by the margin of resection even among the thicker or ulcerated lesions. It also was not affected significantly by the method of closure of the primary site or management of the regional nodes, or the age or gender of the patients. Conclusions: A 2-cm margin is as effective as a 4-cm margin in local control and survival of intermediate-thickness melanomas. The local recurrence rate is significantly affected by the thickness of the primary lesion and the presence or not of ulceration.

AB - Background: In the past, radical margins of excision were prescribed for cutaneous melanoma based on preconceived notions rather than on hard clinical evidence. Methods: In a prospective study of 742 patients with intermediate-thickness melanoma (1-4 mm), 470 patients with trunk or proximal extremity lesions were randomized into a 2-or 4-cm margin. Patients with distal extremity or head and neck lesions (n = 272) received uniformly a 2-cm margin. Results: The overall rate of local recurrence was 3.8%. This rate in the randomized portion (n = 470) was 2.1% for the 2-cm margin and 2.6% for the 4-cm margin (p = 0.72). A progressive increase in local recurrence rates was observed with thickness: 2.3% for lesions 1.0-2.0 mm, 4.2% for those 2.01-3.0 mm, and 11.7% for those 3.01-4.0 mm thick (p = 0.001). Local recurrence occurred in 1.5% of those without ulceration and in 10.6% of those with ulceration of the primary lesion (p = 0.001). The local recurrence rate was not significantly affected by the margin of resection even among the thicker or ulcerated lesions. It also was not affected significantly by the method of closure of the primary site or management of the regional nodes, or the age or gender of the patients. Conclusions: A 2-cm margin is as effective as a 4-cm margin in local control and survival of intermediate-thickness melanomas. The local recurrence rate is significantly affected by the thickness of the primary lesion and the presence or not of ulceration.

KW - Local recurrence

KW - Melanoma

KW - Resection margins

UR - http://www.scopus.com/inward/record.url?scp=0030226546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030226546&partnerID=8YFLogxK

M3 - Article

C2 - 8876886

AN - SCOPUS:0030226546

VL - 3

SP - 446

EP - 452

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 5

ER -