TY - JOUR
T1 - Local infusion therapy in the monkey brainstem
T2 - technical considerations.
AU - Jallo, George I.
AU - Becker, Marc
AU - Liu, Y. J.
AU - Carson, Benjamin S.
AU - Guarnieri, Michael
PY - 2006
Y1 - 2006
N2 - This chapter assesses the safety of freehand placement of an infusion catheter (outer diameter, 0.3 mm) in brainstems of cynomolgus monkeys (Macaca fascicularis) for local infusion therapy. A posterior midline approach through the cerebellum and roof of the fourth ventricle was used to implant catheters into a pontine target area. Computer tomography (CT), magnetic resonance imaging (MRI), and histology were used to examine the position of the implants. The freehand placement of a catheter resulted in approximately 5-mm variations in anterior-posterior and dorsal-ventral locations of the targeted implantation site. No evidence of morbidity from the surgery, or from the infusion process was present. In conclusion, small-diameter catheters for chronic drug infusions can be implanted safely into the brainstem, an eloquent region that has been considered surgically inoperable. Infusion systems may offer a minimally invasive, generally applicable tool to provide chronic therapy for central nervous system (CNS) lesions.
AB - This chapter assesses the safety of freehand placement of an infusion catheter (outer diameter, 0.3 mm) in brainstems of cynomolgus monkeys (Macaca fascicularis) for local infusion therapy. A posterior midline approach through the cerebellum and roof of the fourth ventricle was used to implant catheters into a pontine target area. Computer tomography (CT), magnetic resonance imaging (MRI), and histology were used to examine the position of the implants. The freehand placement of a catheter resulted in approximately 5-mm variations in anterior-posterior and dorsal-ventral locations of the targeted implantation site. No evidence of morbidity from the surgery, or from the infusion process was present. In conclusion, small-diameter catheters for chronic drug infusions can be implanted safely into the brainstem, an eloquent region that has been considered surgically inoperable. Infusion systems may offer a minimally invasive, generally applicable tool to provide chronic therapy for central nervous system (CNS) lesions.
UR - http://www.scopus.com/inward/record.url?scp=39049174879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049174879&partnerID=8YFLogxK
M3 - Article
C2 - 17029190
AN - SCOPUS:39049174879
SN - 1090-3941
VL - 15
SP - 311
EP - 316
JO - Surgical technology international
JF - Surgical technology international
ER -