Local excision and mucosal advancement for anorectal ulceration in patients infected with human immunodeficiency virus

E. C J Consten, J. F M Slors, S. A. Danner, G. J A Offerhaus, J. F W M Bartelsman, J. J B Van Lanschot

Research output: Contribution to journalArticle

Abstract

In patients infected with human immunodeficiency virus no effective surgical procedure has been described for anorectal ulceration that is resistant to medical therapy. This study was designed to determine the effectiveness of surgical excision of anorectal ulcers, with or without mucosal advancement. The medical records of patients with HIV and anorectal pathology diagnosed between 1984 and 1994 were reviewed. Patients with anorectal ulcers were divided into group A which was treated only with excision and group B in which excision was combined with mucosal advancement. Surgical treatment was considered successful if relief of symptoms was achieved within 4 weeks of the operation. Excision of anorectal ulcers was successful in seven of 16 patients (44 per cent) in group A. Relief of symptoms was achieved in 12 of 13 patients (92 per cent) in group B when surgical excision was combined with mucosal advancement, which is significantly better than the results in group A (P = 0.02). This non-randomized study indicates that after unsuccessful medical treatment persistent symptomatic ulcers should be treated operatively by excision with mucosal advancement.

Original languageEnglish (US)
Pages (from-to)891-894
Number of pages4
JournalBritish Journal of Surgery
Volume82
Issue number7
DOIs
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Local excision and mucosal advancement for anorectal ulceration in patients infected with human immunodeficiency virus'. Together they form a unique fingerprint.

  • Cite this

    Consten, E. C. J., Slors, J. F. M., Danner, S. A., Offerhaus, G. J. A., Bartelsman, J. F. W. M., & Van Lanschot, J. J. B. (1995). Local excision and mucosal advancement for anorectal ulceration in patients infected with human immunodeficiency virus. British Journal of Surgery, 82(7), 891-894. https://doi.org/10.1002/bjs.1800820710