Local dynamics and viscoelastic properties of cell biological systems

Yiider Tseng, Thomas P. Kole, Ssu Hsien J Lee, Denis Wirtz

Research output: Contribution to journalArticle

Abstract

How the cytoskeleton, a heterogeneous network of dynamic filamentous proteins, provides the cell with structural support is not well understood. Particle-tracking methods, which probe local mechanical properties, are well suited to test existing hypotheses derived from in vitro models of reconstituted cytoskeleton networks. This paper reviews recent applications of single- and multiple-particle tracking microrheology, with an emphasis on the semiflexible polymer F-actin and the flexible polymer keratin, two ubiquitous proteins of the cytoskeleton. Extensive knowledge of the properties of these polymers allows a rigorous comparison between theory and experiments to a level rarely matched by synthetic polymers.

Original languageEnglish (US)
Pages (from-to)210-217
Number of pages8
JournalCurrent Opinion in Colloid and Interface Science
Volume7
Issue number3-4
DOIs
StatePublished - Aug 2002

Fingerprint

Biological systems
Polymers
polymers
keratins
proteins
Proteins
Keratin
Heterogeneous networks
Keratins
Actins
mechanical properties
Mechanical properties
cells
Experiments

Keywords

  • Cytoskeleton
  • F-Actin
  • Keratin
  • Microrheology
  • Particle tracking

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

Cite this

Local dynamics and viscoelastic properties of cell biological systems. / Tseng, Yiider; Kole, Thomas P.; Lee, Ssu Hsien J; Wirtz, Denis.

In: Current Opinion in Colloid and Interface Science, Vol. 7, No. 3-4, 08.2002, p. 210-217.

Research output: Contribution to journalArticle

Tseng, Yiider ; Kole, Thomas P. ; Lee, Ssu Hsien J ; Wirtz, Denis. / Local dynamics and viscoelastic properties of cell biological systems. In: Current Opinion in Colloid and Interface Science. 2002 ; Vol. 7, No. 3-4. pp. 210-217.
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