Local delivery of antineoplastic agents using biodegradable polymers for the treatment of malignant brain tumors

Federico G. Legnani, Gustavo Pradilla, Paul P. Wang, Henry Brem, Alessandro Olivi, Francesco DiMeco

Research output: Contribution to journalReview article

Abstract

The prognosis for patients diagnosed with malignant brain tumors has remained dismal despite advances in both neuroimaging and conventional treatment modalities. The use of biodegradable polymers for controlled local delivery of antineoplastic agents represents a major advance in the treatment of brain tumors. By implanting polymers loaded with chemotherapy agents directly onto the brain tumor resection bed, therapeutic doses of a drug can be administered intracranially for prolonged periods of time meaning high systemic doses associated with debilitating toxicities can be avoided. This technological advance has expanded the spectrum of available treatments for neoplasms of the CNS and has facilitated new approaches for the treatment of malignant brain tumors.

Original languageEnglish (US)
Pages (from-to)533-546
Number of pages14
JournalExpert review of neurotherapeutics
Volume3
Issue number4
DOIs
StatePublished - Jul 2003

Keywords

  • Biodegradable polymers
  • Brain tumor
  • Drug delivery
  • Glioblastoma multiforme
  • Microspheres

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

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