Local delivery of antineoplastic agents by controlled-release polymers for the treatment of malignant brain tumours

Shaan M. Raza, Gustavo Pradilla, Federico G. Legnani, Quoc Anh Thai, Alessandro Olivi, Jon D. Weingart, Henry Brem

Research output: Contribution to journalReview article

Abstract

Recent advances in the treatment of malignant brain tumours have focused on the development of targeted local delivery of therapeutic agents, which combine various antineoplastic strategies that include cytotoxic, antiangiogenic and immunomodulatory mechanisms, among others. The introduction of local delivery devices for sustained administration of antineoplastic agents represents a new opportunity to effectively treat these malignancies by facilitating the intracranial administration of safe and clinically efficacious doses for prolonged periods of time in a controlled fashion. This technology circumvents the need for high systemic doses with potentially harmful toxicities, bypasses the blood-brain barrier and can be tailored to deliver new agents with complex pharmacological properties. Based on local delivery strategies, new delivery systems, including convection-enhanced delivery and microchips, have been developed. As a result, recent advances in tumour biology have been adopted as potentially translatable treatments and are undergoing preclinical and clinical evaluation at present. These novel approaches could improve the prognosis of patients with these tumours.

Original languageEnglish (US)
Pages (from-to)477-494
Number of pages18
JournalExpert Opinion on Biological Therapy
Volume5
Issue number4
DOIs
StatePublished - Apr 1 2005

Keywords

  • Angiogenesis
  • Brain tumour
  • Controlled-release polymers
  • Convection-enhanced delivery
  • Glioblastoma multiforme
  • Immunotherapy
  • Local delivery
  • Microchip

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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