Local control and reduced complications in split course irradiation of prostatic cancer

Jose L. Pino y Torres; Ding Jen Lee; Steven A. Leibel; Moody D. Wharam; Brett B. Cantrell; Dean S. Bross; Stanley E. Order

doi:10.1016/0360-3016(81)90058-4

Local control and reduced complications in split course irradiation of prostatic cancer

Jose L. Pino y Torres, Ding Jen Lee, Steven A. Leibel, Moody D. Wharam, Brett B. Cantrell, Dean S. Bross, Stanley E. Order

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Split course prostatic irradiation is a treatment technique where 4000-4500 rod whole pelvis irradiation is followed by two weeks of rest and an additional 2000-2500 rod by reduced field technique to a total dose of 6000-6500 rod. Eighty-four patients were studied and the results indicated a local regional control rate of 97.6% with an overall 3 year survival without evidence of disease of 96.6% for Stages A and B and 60% for Stage c. Significant complications occurred in 1.2 % of the patients. None of the patients needed surgical correction of a complication other than a perineal abscess. The risk/benefit ratio for pelvic and prostatic irradiation favors split course prostatic irradiation in that it demonstrates a low complication rate, high local regional control, and comparable disease-free survival to continuous irradiation.

Original language	English (US)
Pages (from-to)	43-47
Number of pages	5
Journal	International journal of radiation oncology, biology, physics
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/0360-3016(81)90058-4
State	Published - Jan 1981
Externally published	Yes

Keywords

External radiation
Megavoltage
Prostatic cancer

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/0360-3016(81)90058-4

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@article{e043de95338b4128a584992d44ee52cd,

title = "Local control and reduced complications in split course irradiation of prostatic cancer",

abstract = "Split course prostatic irradiation is a treatment technique where 4000-4500 rod whole pelvis irradiation is followed by two weeks of rest and an additional 2000-2500 rod by reduced field technique to a total dose of 6000-6500 rod. Eighty-four patients were studied and the results indicated a local regional control rate of 97.6% with an overall 3 year survival without evidence of disease of 96.6% for Stages A and B and 60% for Stage c. Significant complications occurred in 1.2 % of the patients. None of the patients needed surgical correction of a complication other than a perineal abscess. The risk/benefit ratio for pelvic and prostatic irradiation favors split course prostatic irradiation in that it demonstrates a low complication rate, high local regional control, and comparable disease-free survival to continuous irradiation.",

keywords = "External radiation, Megavoltage, Prostatic cancer",

author = "{Pino y Torres}, {Jose L.} and Lee, {Ding Jen} and Leibel, {Steven A.} and Wharam, {Moody D.} and Cantrell, {Brett B.} and Bross, {Dean S.} and Order, {Stanley E.}",

note = "Funding Information: 5. Professor and Director of Radiation Oncology, The Johns Hopkins Hospital, Baltimore, MD. Supported by NationalI nstitrteo f Health, National Cancer Institute CA-O6973-16 and CA-25905-01. Reprint requests to: J. L. Pino y Torres, M.D., Radiation Oncology, The Johns Hopkins Hospital, 600 North Wolfe St., Baltimore, MD 21205. Accepted for publication 27 August 1980.",

year = "1981",

month = jan,

doi = "10.1016/0360-3016(81)90058-4",

language = "English (US)",

volume = "7",

pages = "43--47",

journal = "International journal of radiation oncology, biology, physics",

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AU - Pino y Torres, Jose L.

AU - Lee, Ding Jen

AU - Leibel, Steven A.

AU - Wharam, Moody D.

AU - Cantrell, Brett B.

AU - Bross, Dean S.

AU - Order, Stanley E.

N1 - Funding Information: 5. Professor and Director of Radiation Oncology, The Johns Hopkins Hospital, Baltimore, MD. Supported by NationalI nstitrteo f Health, National Cancer Institute CA-O6973-16 and CA-25905-01. Reprint requests to: J. L. Pino y Torres, M.D., Radiation Oncology, The Johns Hopkins Hospital, 600 North Wolfe St., Baltimore, MD 21205. Accepted for publication 27 August 1980.

PY - 1981/1

Y1 - 1981/1

N2 - Split course prostatic irradiation is a treatment technique where 4000-4500 rod whole pelvis irradiation is followed by two weeks of rest and an additional 2000-2500 rod by reduced field technique to a total dose of 6000-6500 rod. Eighty-four patients were studied and the results indicated a local regional control rate of 97.6% with an overall 3 year survival without evidence of disease of 96.6% for Stages A and B and 60% for Stage c. Significant complications occurred in 1.2 % of the patients. None of the patients needed surgical correction of a complication other than a perineal abscess. The risk/benefit ratio for pelvic and prostatic irradiation favors split course prostatic irradiation in that it demonstrates a low complication rate, high local regional control, and comparable disease-free survival to continuous irradiation.

AB - Split course prostatic irradiation is a treatment technique where 4000-4500 rod whole pelvis irradiation is followed by two weeks of rest and an additional 2000-2500 rod by reduced field technique to a total dose of 6000-6500 rod. Eighty-four patients were studied and the results indicated a local regional control rate of 97.6% with an overall 3 year survival without evidence of disease of 96.6% for Stages A and B and 60% for Stage c. Significant complications occurred in 1.2 % of the patients. None of the patients needed surgical correction of a complication other than a perineal abscess. The risk/benefit ratio for pelvic and prostatic irradiation favors split course prostatic irradiation in that it demonstrates a low complication rate, high local regional control, and comparable disease-free survival to continuous irradiation.

KW - External radiation

KW - Megavoltage

KW - Prostatic cancer

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Local control and reduced complications in split course irradiation of prostatic cancer

Abstract

Keywords

ASJC Scopus subject areas

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