TY - JOUR
T1 - Lobular breast cancer
T2 - Pathology, biology, and options for clinical intervention
AU - Vlug, Eva
AU - Ercan, Cigdem
AU - Van Der Wall, Elsken
AU - Van Diest, Paul J.
AU - Derksen, Patrick W.B.
PY - 2014/2
Y1 - 2014/2
N2 - Lobular carcinoma is a breast cancer subtype comprising approximately 15 % of all breast cancer cases. Clinical diagnosis of this subtype is difficult due to a characteristic growth pattern that inhibits detection using palpation or standard X-ray mammography. While clinical intervention based on hormone antagonists has proven an effective strategy, hormone receptor negative or nonresponsive disease cannot be treated successfully, indicating the need for alternative curative approaches. In contrast to its well-defined histopathological characteristics that were first recognized a century ago, the surface of the underlying biology has only recently been scratched. Progress was made in understanding the biology of the disease, which will hopefully have its impact on future treatment modalities and initiate development of novel intervention strategies. Here, we review the pathological and molecular features of lobular breast cancer and report on the currently known mechanisms that control disease development and progression. Finally we will reflect on past, present, and future treatment options.
AB - Lobular carcinoma is a breast cancer subtype comprising approximately 15 % of all breast cancer cases. Clinical diagnosis of this subtype is difficult due to a characteristic growth pattern that inhibits detection using palpation or standard X-ray mammography. While clinical intervention based on hormone antagonists has proven an effective strategy, hormone receptor negative or nonresponsive disease cannot be treated successfully, indicating the need for alternative curative approaches. In contrast to its well-defined histopathological characteristics that were first recognized a century ago, the surface of the underlying biology has only recently been scratched. Progress was made in understanding the biology of the disease, which will hopefully have its impact on future treatment modalities and initiate development of novel intervention strategies. Here, we review the pathological and molecular features of lobular breast cancer and report on the currently known mechanisms that control disease development and progression. Finally we will reflect on past, present, and future treatment options.
KW - Clinical features
KW - Lobular breast cancer
KW - Molecular features
KW - Pathological features
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U2 - 10.1007/s00005-013-0251-0
DO - 10.1007/s00005-013-0251-0
M3 - Review article
C2 - 23959112
AN - SCOPUS:84895068647
SN - 0004-069X
VL - 62
SP - 7
EP - 21
JO - Archivum Immunologiae et Therapiae Experimentalis
JF - Archivum Immunologiae et Therapiae Experimentalis
IS - 1
ER -