LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis

Xiang Song Wu; Fang Wang; Huai Feng Li; Yun Ping Hu; Lin Jiang; Fei Zhang; Mao Lan Li; Xu An Wang; Yun Peng Jin; Yi Jian Zhang; Wei Lu; Wen Guang Wu; Yi Jun Shu; Hao Weng; Yang Cao; Run Fa Bao; Hai Bin Liang; Zheng Wang; Yi Chi Zhang; Wei Gong; Lei Zheng; Shu Han Sun; Ying Bin Liu

doi:10.15252/embr.201744147

LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis

Xiang Song Wu, Fang Wang, Huai Feng Li, Yun Ping Hu, Lin Jiang, Fei Zhang, Mao Lan Li, Xu An Wang, Yun Peng Jin, Yi Jian Zhang, Wei Lu, Wen Guang Wu, Yi Jun Shu, Hao Weng, Yang Cao, Run Fa Bao, Hai Bin Liang, Zheng Wang, Yi Chi Zhang, Wei GongLei Zheng, Shu Han Sun, Ying Bin Liu

School of Medicine

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.

Original language	English (US)
Pages (from-to)	1837-1853
Number of pages	17
Journal	EMBO Reports
Volume	18
Issue number	10
DOIs	https://doi.org/10.15252/embr.201744147
State	Published - Oct 2017

Keywords

PAGBC
ceRNA
gallbladder cancer
lncRNA
prognosis

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics

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10.15252/embr.201744147

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Wu, X. S., Wang, F., Li, H. F., Hu, Y. P., Jiang, L., Zhang, F., Li, M. L., Wang, X. A., Jin, Y. P., Zhang, Y. J., Lu, W., Wu, W. G., Shu, Y. J., Weng, H., Cao, Y., Bao, R. F., Liang, H. B., Wang, Z., Zhang, Y. C., ... Liu, Y. B. (2017). LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis. EMBO Reports, 18(10), 1837-1853. https://doi.org/10.15252/embr.201744147

Wu, XS, Wang, F, Li, HF, Hu, YP, Jiang, L, Zhang, F, Li, ML, Wang, XA, Jin, YP, Zhang, YJ, Lu, W, Wu, WG, Shu, YJ, Weng, H, Cao, Y, Bao, RF, Liang, HB, Wang, Z, Zhang, YC, Gong, W, Zheng, L, Sun, SH & Liu, YB 2017, 'LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis', EMBO Reports, vol. 18, no. 10, pp. 1837-1853. https://doi.org/10.15252/embr.201744147

@article{73a43f5eca8c42c4a856329860d13506,

title = "LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis",

abstract = "Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.",

keywords = "PAGBC, ceRNA, gallbladder cancer, lncRNA, prognosis",

author = "Wu, {Xiang Song} and Fang Wang and Li, {Huai Feng} and Hu, {Yun Ping} and Lin Jiang and Fei Zhang and Li, {Mao Lan} and Wang, {Xu An} and Jin, {Yun Peng} and Zhang, {Yi Jian} and Wei Lu and Wu, {Wen Guang} and Shu, {Yi Jun} and Hao Weng and Yang Cao and Bao, {Run Fa} and Liang, {Hai Bin} and Zheng Wang and Zhang, {Yi Chi} and Wei Gong and Lei Zheng and Sun, {Shu Han} and Liu, {Ying Bin}",

note = "Funding Information: This study was supported by the National Natural Science Foundation of China (No. 81502433, 31620103910 and 91440203), the Program for Changjiang Scholars, the Leading Talent Program of Shanghai, the Shanghai Rising-Star Program (No. 15QA1403100), the Shanghai Science and Technology Commission Key Basic Research Program (No. 16JC1400200), the Key Program of Shanghai Science and Technology Commission (No. 16411952501), the Multiple Central Clinical Research Program of Shanghai Jiao Tong University School of Medicine (No. DLY201507), the Precision Medicine Research Program of Shanghai Jiao Tong University School of Medicine (No. 15ZH4003), the Doctoral Innovation Fund Projects from Shanghai Jiao Tong University School of Medicine (No. BXJ201426) and the Hangzhou Science and Technology Commission Project (No. 20140633B04). Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = oct,

doi = "10.15252/embr.201744147",

language = "English (US)",

volume = "18",

pages = "1837--1853",

journal = "EMBO Reports",

issn = "1469-221X",

publisher = "Nature Publishing Group",

number = "10",

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TY - JOUR

T1 - LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis

AU - Wu, Xiang Song

AU - Wang, Fang

AU - Li, Huai Feng

AU - Hu, Yun Ping

AU - Jiang, Lin

AU - Zhang, Fei

AU - Li, Mao Lan

AU - Wang, Xu An

AU - Jin, Yun Peng

AU - Zhang, Yi Jian

AU - Lu, Wei

AU - Wu, Wen Guang

AU - Shu, Yi Jun

AU - Weng, Hao

AU - Cao, Yang

AU - Bao, Run Fa

AU - Liang, Hai Bin

AU - Wang, Zheng

AU - Zhang, Yi Chi

AU - Gong, Wei

AU - Zheng, Lei

AU - Sun, Shu Han

AU - Liu, Ying Bin

N1 - Funding Information: This study was supported by the National Natural Science Foundation of China (No. 81502433, 31620103910 and 91440203), the Program for Changjiang Scholars, the Leading Talent Program of Shanghai, the Shanghai Rising-Star Program (No. 15QA1403100), the Shanghai Science and Technology Commission Key Basic Research Program (No. 16JC1400200), the Key Program of Shanghai Science and Technology Commission (No. 16411952501), the Multiple Central Clinical Research Program of Shanghai Jiao Tong University School of Medicine (No. DLY201507), the Precision Medicine Research Program of Shanghai Jiao Tong University School of Medicine (No. 15ZH4003), the Doctoral Innovation Fund Projects from Shanghai Jiao Tong University School of Medicine (No. BXJ201426) and the Hangzhou Science and Technology Commission Project (No. 20140633B04). Publisher Copyright: © 2017 The Authors

PY - 2017/10

Y1 - 2017/10

N2 - Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.

AB - Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.

KW - PAGBC

KW - ceRNA

KW - gallbladder cancer

KW - lncRNA

KW - prognosis

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AN - SCOPUS:85028967538

VL - 18

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EP - 1853

JO - EMBO Reports

JF - EMBO Reports

SN - 1469-221X

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ER -

LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis

Abstract

Keywords

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