@article{73a43f5eca8c42c4a856329860d13506,
title = "LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis",
abstract = "Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.",
keywords = "PAGBC, ceRNA, gallbladder cancer, lncRNA, prognosis",
author = "Wu, {Xiang Song} and Fang Wang and Li, {Huai Feng} and Hu, {Yun Ping} and Lin Jiang and Fei Zhang and Li, {Mao Lan} and Wang, {Xu An} and Jin, {Yun Peng} and Zhang, {Yi Jian} and Wei Lu and Wu, {Wen Guang} and Shu, {Yi Jun} and Hao Weng and Yang Cao and Bao, {Run Fa} and Liang, {Hai Bin} and Zheng Wang and Zhang, {Yi Chi} and Wei Gong and Lei Zheng and Sun, {Shu Han} and Liu, {Ying Bin}",
note = "Funding Information: This study was supported by the National Natural Science Foundation of China (No. 81502433, 31620103910 and 91440203), the Program for Changjiang Scholars, the Leading Talent Program of Shanghai, the Shanghai Rising-Star Program (No. 15QA1403100), the Shanghai Science and Technology Commission Key Basic Research Program (No. 16JC1400200), the Key Program of Shanghai Science and Technology Commission (No. 16411952501), the Multiple Central Clinical Research Program of Shanghai Jiao Tong University School of Medicine (No. DLY201507), the Precision Medicine Research Program of Shanghai Jiao Tong University School of Medicine (No. 15ZH4003), the Doctoral Innovation Fund Projects from Shanghai Jiao Tong University School of Medicine (No. BXJ201426) and the Hangzhou Science and Technology Commission Project (No. 20140633B04).",
year = "2017",
month = oct,
doi = "10.15252/embr.201744147",
language = "English (US)",
volume = "18",
pages = "1837--1853",
journal = "EMBO Reports",
issn = "1469-221X",
publisher = "Nature Publishing Group",
number = "10",
}