LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis

Xiang Song Wu, Fang Wang, Huai Feng Li, Yun Ping Hu, Lin Jiang, Fei Zhang, Mao Lan Li, Xu An Wang, Yun Peng Jin, Yi Jian Zhang, Wei Lu, Wen Guang Wu, Yi Jun Shu, Hao Weng, Yang Cao, Run Fa Bao, Hai Bin Liang, Zheng Wang, Yi Chi Zhang, Wei GongLei Zheng, Shu Han Sun, Ying Bin Liu

Research output: Contribution to journalArticlepeer-review

Abstract

Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.

Original languageEnglish (US)
Pages (from-to)1837-1853
Number of pages17
JournalEMBO Reports
Volume18
Issue number10
DOIs
StatePublished - Oct 2017

Keywords

  • PAGBC
  • ceRNA
  • gallbladder cancer
  • lncRNA
  • prognosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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