TY - JOUR
T1 - Living-donor renal transplantation in seopf
T2 - The impact of histocompatibility, transfusios, and cyclosporine on outcome
AU - Sanfilippo, Fred
AU - Thacker, Leroy
AU - Vaughn, William K.
PY - 1990
Y1 - 1990
N2 - The impact of haplotype match (HM), pretransplant transfusions, and cyclosporine use were examined for living-donor renal transplants performed among 49 centers in the South-Eastern Organ Procurement Foundation (SEOPF) from November 1983 to June 1988 with follow-up through March 1989. During this period, 750 2-HM, 1246 1-HM, and 120 O-HM living-donor transplants were performed at 46, 47, and 27 centers, respectively. Demographic comparisons of the HM categories demonstrated the greatest use of cyclosporine and donor-specific transfusions in the O-HM group, and the greatest use of random blood transfusions (RBT) or no blood transfusions (NBT) in the 2-HM group. By univariate and multivariate (Cox regression) analyses, actuarial graft survival was significantly associated with haplotype match, although excellent 3-year graft survival was seen for O-HM as well as 1-HM and 2-HM first transplant recipients: 74 ± 5%, 80 ± 2%, and 85 ± 2%, respectively. Comparisons were also made among patients receiving DST±CsA, RBTiCsA, and NBT±CsA for each HM group by univariate and mutivariate analyses. For O-HM recipients, DST+CsA was most frequently used and associated with the best long-term survival (86±5% at 3 years) by univariate analysis. For 1-HM recipients, there were no apparent differences in graft survival between DST and RBT groups ± CsA by univariate analysis, but the absence of transfusion (NBT±CsA) was associated with the poorest 3-year survival (79±4%). This was confirmed by multivariate analysis, where DST (P
AB - The impact of haplotype match (HM), pretransplant transfusions, and cyclosporine use were examined for living-donor renal transplants performed among 49 centers in the South-Eastern Organ Procurement Foundation (SEOPF) from November 1983 to June 1988 with follow-up through March 1989. During this period, 750 2-HM, 1246 1-HM, and 120 O-HM living-donor transplants were performed at 46, 47, and 27 centers, respectively. Demographic comparisons of the HM categories demonstrated the greatest use of cyclosporine and donor-specific transfusions in the O-HM group, and the greatest use of random blood transfusions (RBT) or no blood transfusions (NBT) in the 2-HM group. By univariate and multivariate (Cox regression) analyses, actuarial graft survival was significantly associated with haplotype match, although excellent 3-year graft survival was seen for O-HM as well as 1-HM and 2-HM first transplant recipients: 74 ± 5%, 80 ± 2%, and 85 ± 2%, respectively. Comparisons were also made among patients receiving DST±CsA, RBTiCsA, and NBT±CsA for each HM group by univariate and mutivariate analyses. For O-HM recipients, DST+CsA was most frequently used and associated with the best long-term survival (86±5% at 3 years) by univariate analysis. For 1-HM recipients, there were no apparent differences in graft survival between DST and RBT groups ± CsA by univariate analysis, but the absence of transfusion (NBT±CsA) was associated with the poorest 3-year survival (79±4%). This was confirmed by multivariate analysis, where DST (P
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M3 - Article
C2 - 2301022
AN - SCOPUS:0025177195
SN - 0041-1337
VL - 49
SP - 25
EP - 29
JO - Transplantation
JF - Transplantation
IS - 1
ER -