Liver X receptors in atherosclerosis and inflammation

Seung Soon Im, Timothy F. Osborne

Research output: Contribution to journalReview articlepeer-review

Abstract

Liver X receptors (LXRs) are cholesterol-sensing nuclear receptors that are not only key regulators of lipid metabolism and transport but also suppress inflammatory signaling in macrophages through a unique mechanism of transrepression. In this brief review, we focus on the regulatory actions of LXR primarily in macrophages responding to a proatherogenic environment. LXR potentially interferes with atherosclerosis by 2 different agonist-dependent signaling pathways. The first is through promoting reverse cholesterol transportby directly activating genes of cellular cholesterol export. The second is through a general inhibitory action on proinflammatory genes where sumo-modified and agonist-bound LXR recruits negative coregulatory proteins to nuclear factor κB at immune response gene promoters through protein-protein interactions. The antiinflammatory actions of LXR may be a direct response to the proinflammatory actions recently proposed for cholesterol on inflammasome activity in the vessel wall.

Original languageEnglish (US)
Pages (from-to)996-1001
Number of pages6
JournalCirculation research
Volume108
Issue number8
DOIs
StatePublished - Apr 15 2011

Keywords

  • Inflammation
  • LXR
  • atherosclerosis
  • innate immune response
  • liver X receptor

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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