Liver transplantation improves cirrhosis-associated impaired oral glucose tolerance

Archana Shetty, Sharon Wilson, Paul Kuo, Jacqueline L. Laurin, Charles D. Howell, Lynt Johnson, Elsie M. Allen

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Thirty-five percent to 80% of cirrhotic patients have impaired glucose tolerance (IGT) or diabetes mellitus (DM). Diabetic cirrhotics have higher morbidity and mortality than nondiabetics. Therefore, it would be worthwhile to determine whether liver transplantation improves glucose homeostasis in these patients. Method. A total of 26 patients awaiting liver transplantation were evaluated for impaired glucose homeostasis by fasting blood glucose and/or oral glucose tolerance tests (OGTT). Five patients underwent transplant surgery within 1 year of OGTT and had a repeat OGTT 3-6 months after transplantation. Results. Sixty-five percent (17/26) of the patients had abnormal glucose homeostasis. Twenty- three percent (6/26) met American Diabetes Association criteria for DM, and another 42.3% (11/26) had IGT. All patients had normal HbA1C levels. After transplantation, the 2-hr blood glucose improved in four patients and the mean 2-hr glucose level was reduced (204±94 vs. 132±53 mg/dl [mean±SD, P=0.051]). Conclusion. Liver transplantation can reverse cirrhosis-associated impaired glucose tolerance.

Original languageEnglish (US)
Pages (from-to)2451-2454
Number of pages4
JournalTransplantation
Volume69
Issue number11
DOIs
StatePublished - Jun 15 2000
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

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