Liver transplantation from controlled non-heartbeating donors: An increased incidence of biliary complications

Peter Abt, Michael Crawford, Niraj Desai, James Markmann, Kim Olthoff, Abraham Shaked

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Hepatic allografts from non-heartbeating donors (NHBD) have been cited as a means to expand the supply of donor livers. Concern exists that donor warm ischemic time in addition to subsequent cold ischemia-reperfusion injury may result in damage to sensitive cell populations within the liver. Because the biliary epithelium is sensitive to ischemiareperfusion injury, the authors surmised that an increased incidence of biliary complications might occur among recipients of an NHBD allograft. Methods. This study was a retrospective evaluation of NHBD recipients compared to a group of heartbeating donor (HBD) recipients from a single institution. Results. Fifteen patients received a hepatic allograft from a controlled NHBD donor. NHBD and HBD (n=221) graft survival did not differ at 1 (71.8% vs. 85.4%, P=0.23) or 3 years (71.8% vs. 73.9%, P=0.68). Patient survival at 1 (79% vs. 90.9%, P=0.16) and 3 years (79.0% vs. 77.7%, P=0.8) was also similar. Major biliary complications occurred in five (33.3%) NHBD recipients; 66.6% of the NHBD biliary complications consisted of intrahepatic strictures versus 19.2% among HBD recipients (P<0.01). Major biliary complications in the NHBD recipients resulted in multiple interventional procedures, retransplantation, and death. Conclusions. Donor warm ischemic time may predispose hepatic allografts to an increased incidence of ischemic type strictures. Although graft and patient survival was similar to a cohort of HBD recipients, caution is urged with the use of these organs.

Original languageEnglish (US)
Pages (from-to)1659-1663
Number of pages5
JournalTransplantation
Volume75
Issue number10
DOIs
StatePublished - May 27 2003
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Liver transplantation from controlled non-heartbeating donors: An increased incidence of biliary complications'. Together they form a unique fingerprint.

Cite this