Liver transplantation after an acute episode of spontaneous bacterial peritonitis

David H. Van Thiel, Tarek Hassanein, Ahmet Gurakar, Harlan I. Wright, Paolo Caraceni, Nicola De Maria, Abdul Nadir

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aims: Spontaneous bacterial peritonitis (SBP) is a common complication of advanced cirrhosis. Thus many potential transplant recipients will experience this problem while waiting for a liver donor. The minimal amount of time with the use of appropriate antibiotics after which a potential recipient can be transplanted safely is not currently known. We examined the effect of pretransplant SBP on subsequent post-transplant outcome. Materials and Methods: A retrospective review of the records of 100 liver transplant recipients having an episode of spontaneous bacterial peritonitis within 30 days of their transplant was performed. The records of transplant controls without an episode of spontaneous bacterial peritonitis were reviewed to compare the outcome between the true groups in terms of sepsis during the initial 30 post-transplant days. Results: Post-transplant sepsis occurred in 8.8% of the cases and 10% of the controls (NSO). Only one episode in the study group could be ascribed to the pre-transplant episode of spontaneous bacterial peritonitis and it occurred in an IgA deficient recipient. Conclusions: These data suggest that SBP prior to liver transplantation does not lead to an increased rate of post-operative sepsis if 4 or more days of appropriate treatment for SBP are administered prior to liver transplantation.

Original languageEnglish (US)
Pages (from-to)1584-1588
Number of pages5
JournalHepato-gastroenterology
Volume43
Issue number12
StatePublished - Dec 1 1996
Externally publishedYes

Keywords

  • (SBP)
  • Antibiotic therapy
  • Liver transplantation
  • Peritonitis
  • Spontaneous bacterial peritonitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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