TY - JOUR
T1 - Liver Transplant in Hemoglobin SC Disease and Autoimmune Hepatitis
T2 - A Case Report
AU - Kim, Ahyoung
AU - Assarzadegan, Naziheh
AU - Anders, Robert A.
AU - Oshima, Kiyoko
AU - Chaturvedi, Shruti
AU - Weeks, Sharon
AU - Kohli, Ruhail
AU - Lanzkron, Sophie
AU - Gurakar, Ahmet
AU - Garonzik-Wang, Jacqueline
AU - Chen, Po Hung
N1 - Publisher Copyright:
© Başkent University 2022 Printed in Turkey. All Rights Reserved.
PY - 2022/4
Y1 - 2022/4
N2 - Although liver transplant is a life-saving measure for individuals with end-stage liver disease, the perioperative management may be challenging in individuals with concomitant sickle cell disease. We report a case of a 50-year-old man with sickle cell disease genotype SC (HbSC) and cirrhosis secondary to autoimmune hepatitis who underwent liver transplant. His postoperative course included upper extremity deep vein thrombosis, pulmonary embolus, stroke via a patent foramen ovale after a line removal, and posterior reversible encephalopathy syndrome. Fortunately, he is alive with a functioning graft at 10 months after liver transplant. This case highlights the feasibility of liver transplant in sickle cell disease given the support of meticulous multidisciplinary care and the unique aspects of autoimmune hepatitis and sickle cell disease for liver transplant consideration.
AB - Although liver transplant is a life-saving measure for individuals with end-stage liver disease, the perioperative management may be challenging in individuals with concomitant sickle cell disease. We report a case of a 50-year-old man with sickle cell disease genotype SC (HbSC) and cirrhosis secondary to autoimmune hepatitis who underwent liver transplant. His postoperative course included upper extremity deep vein thrombosis, pulmonary embolus, stroke via a patent foramen ovale after a line removal, and posterior reversible encephalopathy syndrome. Fortunately, he is alive with a functioning graft at 10 months after liver transplant. This case highlights the feasibility of liver transplant in sickle cell disease given the support of meticulous multidisciplinary care and the unique aspects of autoimmune hepatitis and sickle cell disease for liver transplant consideration.
KW - Deep vein thrombosis
KW - End-stage liver disease
KW - Posterior reversible encephalopathy syndrome
UR - http://www.scopus.com/inward/record.url?scp=85129616647&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85129616647&partnerID=8YFLogxK
U2 - 10.6002/ect.2021.0350
DO - 10.6002/ect.2021.0350
M3 - Article
C2 - 34981707
AN - SCOPUS:85129616647
SN - 1304-0855
VL - 20
SP - 429
EP - 432
JO - Experimental and Clinical Transplantation
JF - Experimental and Clinical Transplantation
IS - 4
ER -