Liver regeneration after major liver hepatectomy: Impact of body mass index

Neda Amini, Georgios A. Margonis, Stefan Buttner, Sepideh Besharati, Yuhree Kim, Faiz Gani, Fatemeh Sobhani, Ihab R Kamel, Timothy M. Pawlik

Research output: Contribution to journalArticlepeer-review


Background: Obese patients may present with metabolic abnormalities that impact liver regeneration. We sought to assess the impact of body mass index (BMI) on liver volume regeneration index (RI) and kinetic growth rate (KGR) among patients undergoing liver resection. Methods: The study included 102 patients undergoing major hepatectomy (≥3 segments) between July 2004 and April 2015 and stratified the patients by preoperative BMI, number of segments resected, and postoperative remnant liver volume (RLVp) to total liver volume ratio. Resected volume at operation was subtracted from total liver volume to calculate postoperative RLVp. RI was defined as the relative increase in RLV within 2 months [(RLV2m-RLVp)/RLVp] and 7 months [(RLV7m-RLVp)/RLVp] postoperatively; KGR was calculated as RI divided by time postoperatively (weeks). Results: Median patient age was 59.6 years (interquartile range 48.1-68.7 years), and most patients were men (52.0%). Liver failure was associated with the KGR at 2 months (KGR2m) and was greater among patients with KGR2m 2-7m compared with patients of normal BMI (0.82% per week; P <.05). Additionally, risk of a major complication was greatest among obese patients (normal weight, 8.1% vs overweight, 12.9% vs obese, 29.4%; P = .04). Conclusion: BMI did not impact liver regeneration during the first 2 months. In contrast, KGR per week between 2 and 7 months postoperatively was less among overweight and obese patients.

Original languageEnglish (US)
StateAccepted/In press - 2016

ASJC Scopus subject areas

  • Surgery

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