This chapter is focused on the discussion and review of benign and malignant liver lesions. The differential diagnosis of a liver mass is broad, including both benign and malignant tumor. The liver is also frequently involved by the metastasis in cancer patients; therefore, the FNA cytology plays a critical role in the work up of liver masses. Although most liver lesions can be accurately diagnosed by FNA, the limitation of the FNA cytology should also be considered. For example, the diagnosis of focal nodular hyperplasia (FNH), hepatic adenoma, and regenerative nodule may not be made based on cytomorphology. Nevertheless, the false-positive diagnosis is rare in daily practice.
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