Liver Disease in the HIV-Infected Individual

Jennifer C. Price, Chloe L. Thio

Research output: Contribution to journalReview articlepeer-review

Abstract

Since the advent of effective antiretroviral therapy (ART) for human immunodeficiency virus-1 (HIV), there has been a substantial decrease in deaths related to acquired immunodeficiency syndrome (AIDS). However, in the ART era, liver disease is now the most common non-AIDS-related cause of death among HIV-infected patients, accounting for 14%-18% of all deaths in this population and almost half of deaths among hospitalized HIV-infected patients. Just as the burden of non-AIDS morbidity and mortality has changed in the ART era, the types of liver disease the clinician is likely to encounter among these patients have changed as well. This review will discuss the causes of liver disease in the HIV-infected population in the ART era, including chronic hepatitis C virus, chronic hepatitis B virus, medication-related hepatotoxicity, alcohol abuse, nonalcoholic fatty liver disease, and AIDS-related liver diseases.

Original languageEnglish (US)
Pages (from-to)1002-1012
Number of pages11
JournalClinical Gastroenterology and Hepatology
Volume8
Issue number12
DOIs
StatePublished - Dec 2010

Keywords

  • Hepatitis B Virus
  • Hepatitis C Virus
  • Human Immunodeficiency Virus
  • Liver Disease

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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