Liver-directed therapies in colorectal cancer

Janivette Alsina, Michael A. Choti

Research output: Contribution to journalArticle

Abstract

Colorectal cancer is the third leading cause of cancer-related deaths in the United States. Historically, the majority of patients that presented with metastatic disease to the liver were treated with systemic chemotherapy only but advances in imaging, surgical techniques, and non-resectional approaches have expanded the indications for liver-directed interventions. Current approaches used in patients with liver-only or liver-dominant metastatic disease include surgical resection, direct tumor ablation strategies, the use of intra-arterial infusions, and radiation therapies. The use of these liver-directed therapies in selected patients with colorectal liver metastases has led to significant improvements in overall survival. We review the clinical data and progress using liver-directed therapies in the treatment of colorectal liver metastases.

Original languageEnglish (US)
Pages (from-to)561-567
Number of pages7
JournalSeminars in Oncology
Volume38
Issue number4
DOIs
StatePublished - Aug 2011

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Colorectal Neoplasms
Liver
Therapeutics
Neoplasm Metastasis
Intra Arterial Infusions
Liver Diseases
Neoplasms
Radiotherapy
Drug Therapy
Survival

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Liver-directed therapies in colorectal cancer. / Alsina, Janivette; Choti, Michael A.

In: Seminars in Oncology, Vol. 38, No. 4, 08.2011, p. 561-567.

Research output: Contribution to journalArticle

Alsina, Janivette ; Choti, Michael A. / Liver-directed therapies in colorectal cancer. In: Seminars in Oncology. 2011 ; Vol. 38, No. 4. pp. 561-567.
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