Liver cirrhosis is associated with venous thromboembolism among hospitalized patients in a nationwide US study

Harry Wu, Geoffrey C. Nguyen

Research output: Contribution to journalArticle

Abstract

Background & Aims: Studies on the impact of liver disease on venous thromboembolism (VTE) have produced conflicting results. We assessed the risk of VTE in patients with compensated or decompensated cirrhosis. Methods: Data on hospital discharges of patients with liver cirrhosis and a random sample of control patients (without liver disease, 1%) were analyzed from the Nationwide Inpatient Sample (1998-2006). Prevalence of VTE was compared among patients with and without cirrhosis. The impact of VTE on in-hospital mortality and length of stay (LOS) was assessed. Results: After multivariate adjustment, patients with compensated and decompensated cirrhosis were at higher risk of VTE until the age of 45 years (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.04-1.46 and OR, 1.39; 95% CI, 1.15-1.69, respectively). After 45 years of age, compensated cirrhosis was associated with a modest decrease in adjusted odds of VTE (OR, 0.90; 95% CI, 0.85-0.95) whereas decompensated cirrhosis was not associated with higher risk of VTE (OR, 0.97; 95% CI, 0.91-1.04). VTE was associated with increased mortality among patients with compensated cirrhosis (OR, 2.16; 95% CI, 1.96-2.38) or decompensated cirrhosis (OR, 1.66, 95% CI, 1.47-1.87). VTE was associated with a 103% increase in length of stay (95% CI, 95%-111% increase) among patients with compensated cirrhosis and an 86% increase (95% CI, 78%-94% increase) among those with decompensated cirrhosis. Conclusions: Patients with cirrhosis under the age of 45 years are at higher risk for VTE that those without liver disease and should be considered for VTE prophylaxis.

Original languageEnglish (US)
JournalClinical Gastroenterology and Hepatology
Volume8
Issue number9
DOIs
StatePublished - Sep 2010

Fingerprint

Venous Thromboembolism
Liver Cirrhosis
Fibrosis
Confidence Intervals
Odds Ratio
Liver Diseases
Length of Stay
Patient Discharge
Hospital Mortality
Inpatients

Keywords

  • Deep Venous Thrombosis
  • Hospitalization
  • Liver Cirrhosis
  • Venous Thromboembolism

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Liver cirrhosis is associated with venous thromboembolism among hospitalized patients in a nationwide US study. / Wu, Harry; Nguyen, Geoffrey C.

In: Clinical Gastroenterology and Hepatology, Vol. 8, No. 9, 09.2010.

Research output: Contribution to journalArticle

@article{73b37c1952414de9856cd23a81ca7cb0,
title = "Liver cirrhosis is associated with venous thromboembolism among hospitalized patients in a nationwide US study",
abstract = "Background & Aims: Studies on the impact of liver disease on venous thromboembolism (VTE) have produced conflicting results. We assessed the risk of VTE in patients with compensated or decompensated cirrhosis. Methods: Data on hospital discharges of patients with liver cirrhosis and a random sample of control patients (without liver disease, 1{\%}) were analyzed from the Nationwide Inpatient Sample (1998-2006). Prevalence of VTE was compared among patients with and without cirrhosis. The impact of VTE on in-hospital mortality and length of stay (LOS) was assessed. Results: After multivariate adjustment, patients with compensated and decompensated cirrhosis were at higher risk of VTE until the age of 45 years (odds ratio [OR], 1.23; 95{\%} confidence interval [CI], 1.04-1.46 and OR, 1.39; 95{\%} CI, 1.15-1.69, respectively). After 45 years of age, compensated cirrhosis was associated with a modest decrease in adjusted odds of VTE (OR, 0.90; 95{\%} CI, 0.85-0.95) whereas decompensated cirrhosis was not associated with higher risk of VTE (OR, 0.97; 95{\%} CI, 0.91-1.04). VTE was associated with increased mortality among patients with compensated cirrhosis (OR, 2.16; 95{\%} CI, 1.96-2.38) or decompensated cirrhosis (OR, 1.66, 95{\%} CI, 1.47-1.87). VTE was associated with a 103{\%} increase in length of stay (95{\%} CI, 95{\%}-111{\%} increase) among patients with compensated cirrhosis and an 86{\%} increase (95{\%} CI, 78{\%}-94{\%} increase) among those with decompensated cirrhosis. Conclusions: Patients with cirrhosis under the age of 45 years are at higher risk for VTE that those without liver disease and should be considered for VTE prophylaxis.",
keywords = "Deep Venous Thrombosis, Hospitalization, Liver Cirrhosis, Venous Thromboembolism",
author = "Harry Wu and Nguyen, {Geoffrey C.}",
year = "2010",
month = "9",
doi = "10.1016/j.cgh.2010.05.014",
language = "English (US)",
volume = "8",
journal = "Clinical Gastroenterology and Hepatology",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "9",

}

TY - JOUR

T1 - Liver cirrhosis is associated with venous thromboembolism among hospitalized patients in a nationwide US study

AU - Wu, Harry

AU - Nguyen, Geoffrey C.

PY - 2010/9

Y1 - 2010/9

N2 - Background & Aims: Studies on the impact of liver disease on venous thromboembolism (VTE) have produced conflicting results. We assessed the risk of VTE in patients with compensated or decompensated cirrhosis. Methods: Data on hospital discharges of patients with liver cirrhosis and a random sample of control patients (without liver disease, 1%) were analyzed from the Nationwide Inpatient Sample (1998-2006). Prevalence of VTE was compared among patients with and without cirrhosis. The impact of VTE on in-hospital mortality and length of stay (LOS) was assessed. Results: After multivariate adjustment, patients with compensated and decompensated cirrhosis were at higher risk of VTE until the age of 45 years (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.04-1.46 and OR, 1.39; 95% CI, 1.15-1.69, respectively). After 45 years of age, compensated cirrhosis was associated with a modest decrease in adjusted odds of VTE (OR, 0.90; 95% CI, 0.85-0.95) whereas decompensated cirrhosis was not associated with higher risk of VTE (OR, 0.97; 95% CI, 0.91-1.04). VTE was associated with increased mortality among patients with compensated cirrhosis (OR, 2.16; 95% CI, 1.96-2.38) or decompensated cirrhosis (OR, 1.66, 95% CI, 1.47-1.87). VTE was associated with a 103% increase in length of stay (95% CI, 95%-111% increase) among patients with compensated cirrhosis and an 86% increase (95% CI, 78%-94% increase) among those with decompensated cirrhosis. Conclusions: Patients with cirrhosis under the age of 45 years are at higher risk for VTE that those without liver disease and should be considered for VTE prophylaxis.

AB - Background & Aims: Studies on the impact of liver disease on venous thromboembolism (VTE) have produced conflicting results. We assessed the risk of VTE in patients with compensated or decompensated cirrhosis. Methods: Data on hospital discharges of patients with liver cirrhosis and a random sample of control patients (without liver disease, 1%) were analyzed from the Nationwide Inpatient Sample (1998-2006). Prevalence of VTE was compared among patients with and without cirrhosis. The impact of VTE on in-hospital mortality and length of stay (LOS) was assessed. Results: After multivariate adjustment, patients with compensated and decompensated cirrhosis were at higher risk of VTE until the age of 45 years (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.04-1.46 and OR, 1.39; 95% CI, 1.15-1.69, respectively). After 45 years of age, compensated cirrhosis was associated with a modest decrease in adjusted odds of VTE (OR, 0.90; 95% CI, 0.85-0.95) whereas decompensated cirrhosis was not associated with higher risk of VTE (OR, 0.97; 95% CI, 0.91-1.04). VTE was associated with increased mortality among patients with compensated cirrhosis (OR, 2.16; 95% CI, 1.96-2.38) or decompensated cirrhosis (OR, 1.66, 95% CI, 1.47-1.87). VTE was associated with a 103% increase in length of stay (95% CI, 95%-111% increase) among patients with compensated cirrhosis and an 86% increase (95% CI, 78%-94% increase) among those with decompensated cirrhosis. Conclusions: Patients with cirrhosis under the age of 45 years are at higher risk for VTE that those without liver disease and should be considered for VTE prophylaxis.

KW - Deep Venous Thrombosis

KW - Hospitalization

KW - Liver Cirrhosis

KW - Venous Thromboembolism

UR - http://www.scopus.com/inward/record.url?scp=77956172304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956172304&partnerID=8YFLogxK

U2 - 10.1016/j.cgh.2010.05.014

DO - 10.1016/j.cgh.2010.05.014

M3 - Article

C2 - 20566312

AN - SCOPUS:77956172304

VL - 8

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

IS - 9

ER -