Liver and Gallbladder

Arlin B. Rogers, Renee Z. Dintzis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In both humans and mice, the liver is a regulatory center for nutrient processing, protein production, energy homeostasis, and detoxification. Nutrients are collected from blood arriving from the gastrointestinal tract via the portal vein, and toxins from intestinal bacteria and other sources are cleared. The human liver occupies the right upper quadrant of the abdomen, whereas the mouse liver spans the entire subdiaphragmatic space. Lobe patterns are different between the two species, and the human liver is traversed and suspended by surface ligaments that are not apparent in the mouse. Although lobar patterns are species-specific, basic lobular subunits are highly conserved in structure and function. Nevertheless, adaptations to unique exposures and dietary habits can be reflected even at the histologic level. Mixed arterial and portal venous blood enters the lobule from portal "triads" (actually composed of four structures: arterioles, venules, bile ductules, and lymphatics). Nutrients and macromolecules are freely exchanged between hepatocytes and plasma across sinusoids lined by fenestrated endothelium, while resident cells including hepatic stellate cells, Kupffer cell macrophages, and T and natural killer (NK) cells maintain close immune surveillance. Physiologic function is similar in both species, although there are some key differences reflected at the morphologic level. © 2012

Original languageEnglish (US)
Title of host publicationComparative Anatomy and Histology
PublisherElsevier Inc.
Pages193-201
Number of pages9
ISBN (Print)9780123813619
DOIs
StatePublished - 2012

Fingerprint

Gallbladder
Liver
Food
Hepatic Stellate Cells
Natural Killer T-Cells
Kupffer Cells
Venules
Arterioles
Feeding Behavior
Portal Vein
Ligaments
Bile
Abdomen
Endothelium
Gastrointestinal Tract
Hepatocytes
Homeostasis
Macrophages
Bacteria
Proteins

Keywords

  • Biliary tract
  • Comparative anatomy
  • Comparative histology
  • Gallbladder
  • Liver

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

Cite this

Rogers, A. B., & Dintzis, R. Z. (2012). Liver and Gallbladder. In Comparative Anatomy and Histology (pp. 193-201). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-381361-9.00013-5

Liver and Gallbladder. / Rogers, Arlin B.; Dintzis, Renee Z.

Comparative Anatomy and Histology. Elsevier Inc., 2012. p. 193-201.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rogers, AB & Dintzis, RZ 2012, Liver and Gallbladder. in Comparative Anatomy and Histology. Elsevier Inc., pp. 193-201. https://doi.org/10.1016/B978-0-12-381361-9.00013-5
Rogers AB, Dintzis RZ. Liver and Gallbladder. In Comparative Anatomy and Histology. Elsevier Inc. 2012. p. 193-201 https://doi.org/10.1016/B978-0-12-381361-9.00013-5
Rogers, Arlin B. ; Dintzis, Renee Z. / Liver and Gallbladder. Comparative Anatomy and Histology. Elsevier Inc., 2012. pp. 193-201
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