Liver alcohol dehydrogenase activity in the female rat: Effects of ovariectomy and estradiol administration

Esteban Mezey, James J. Potter, Panayiotis D. Tsitouras

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of ovariectomy and administration of estradiol on the activity of liver alcohol dehydrogenase and on the rate of ethanol elimination were determined in female Sprague-Dawley rats. The activity of the enzyme and the rates of ethanol elimination in the female sham-operated animals were higher than obtained previously in male rats of the same age. Ovariectomy had no effect on liver alcohol dehydrogenase and on rates of ethanol elimination. Estradiol administration resulted in an increase in liver weight and in total liver alcohol dehydrogenase activity per animal in sham-operated but not in ovariectomized animals. The increase in enzyme activity after estradiol administration in sham-operated animals was not associated with a significant increase in the rate of ethanol elimination, suggesting that the enzyme activity in female rats is not rate-limiting in in vivo ethanol oxidation.

Original languageEnglish (US)
Pages (from-to)1171-1176
Number of pages6
JournalLife Sciences
Volume29
Issue number11
DOIs
StatePublished - Sep 14 1981

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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