Live birth patterns among human immunodeficiency virus-infected women before and after the availability of highly active antiretroviral therapy

Anjali Sharma, Joseph G. Feldman, Elizabeth Golub, Julie Schmidt, Sylvia Silver, Esther Robison, Howard Minkoff

Research output: Contribution to journalArticle

Abstract

Objective: The objective of the study was to investigate the relationship between human immunodeficiency virus (HIV) infection and childbearing before and after the availability of highly active antiretroviral therapy (HAART). Methods: Enrollment in the Women's Interagency HIV study took place in 1994-1995 (pre-HAART era) and again in 2001-2002 (HAART era). Live birth rates prior to enrollment were compared between treatment era cohorts for HIV-infected and HIV-uninfected women aged 15-44 years using Poisson regression. For HIV-infected women, we included live births between HIV diagnosis date and study entry; the HAART era cohort included only women diagnosed with HIV in 1996 and afterward. Results: Among HIV-infected women, the HAART era live birth rate was 150% higher than in the pre-HAART era (P = .001) vs a 5% increase among HIV-uninfected women. The rate of increase in live birth rate was higher for women ≥35 years old (vs younger than 25 years, P = .02), and with more than a high school education (vs. less than high school, P = .05). Conclusion: The availability of effective therapeutic interventions has had a profound impact on child-bearing among HIV-infected women.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume196
Issue number6
DOIs
StatePublished - Jun 2007

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Highly Active Antiretroviral Therapy
Live Birth
HIV
Birth Rate
Virus Diseases
Education

Keywords

  • birth rate
  • highly active antiretroviral therapy
  • human immunodeficiency virus
  • reproductive decision making
  • women

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Live birth patterns among human immunodeficiency virus-infected women before and after the availability of highly active antiretroviral therapy. / Sharma, Anjali; Feldman, Joseph G.; Golub, Elizabeth; Schmidt, Julie; Silver, Sylvia; Robison, Esther; Minkoff, Howard.

In: American Journal of Obstetrics and Gynecology, Vol. 196, No. 6, 06.2007.

Research output: Contribution to journalArticle

Sharma, Anjali ; Feldman, Joseph G. ; Golub, Elizabeth ; Schmidt, Julie ; Silver, Sylvia ; Robison, Esther ; Minkoff, Howard. / Live birth patterns among human immunodeficiency virus-infected women before and after the availability of highly active antiretroviral therapy. In: American Journal of Obstetrics and Gynecology. 2007 ; Vol. 196, No. 6.
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