TY - JOUR
T1 - Lithium dampens neurotransmitter response in smooth muscle
T2 - Relevance to action in affective illness
AU - Menkes, H. A.
AU - Baraban, J. M.
AU - Freed, A. N.
AU - Snyder, S. H.
PY - 1986
Y1 - 1986
N2 - Lithium, by inhibiting inositol phosphate metabolism, interferes with the phosphatidylinositol ('phosphinositide') cycle, which is stimulated by numerous hormones and neurtransmitters. To examine the relevance of this action to neurotransmission, we evaluated effects of lithium treatment on smooth muscle responses to transmitters. In lithium-pretreated tracheal muscle, the relaxation following carbachol or histamine contractions is retarded. Lithium does not affect relaxation following contractions elicited by treatment with KCl and phorbol 12,13-diacetate in combination, which bypasses receptor stimulation of the phosphatidylinositol cycle. Half-maximal effects of lithium occur at 1 mM, corresponding to therapeutic concentrations. Dampening of neurotransmitter responses by lithium treatment may explain the unique ability of lithium to relieve and prevent both mania and depression.
AB - Lithium, by inhibiting inositol phosphate metabolism, interferes with the phosphatidylinositol ('phosphinositide') cycle, which is stimulated by numerous hormones and neurtransmitters. To examine the relevance of this action to neurotransmission, we evaluated effects of lithium treatment on smooth muscle responses to transmitters. In lithium-pretreated tracheal muscle, the relaxation following carbachol or histamine contractions is retarded. Lithium does not affect relaxation following contractions elicited by treatment with KCl and phorbol 12,13-diacetate in combination, which bypasses receptor stimulation of the phosphatidylinositol cycle. Half-maximal effects of lithium occur at 1 mM, corresponding to therapeutic concentrations. Dampening of neurotransmitter responses by lithium treatment may explain the unique ability of lithium to relieve and prevent both mania and depression.
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U2 - 10.1073/pnas.83.15.5727
DO - 10.1073/pnas.83.15.5727
M3 - Article
C2 - 2874555
AN - SCOPUS:0022505466
VL - 83
SP - 5727
EP - 5730
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 15
ER -