Lithium blocks a phosphoinositide-mediated cholinergic response in hippocampal slices

Research output: Contribution to journalArticle

Abstract

The effects of lithium on inositol phosphate metabolism may account for the therapeutic actions of lithium in affective disorder. Muscarinic stimulation of the phosphoinositide system blocks synaptic inhibitory actions of adenosine in the hippocampal slice. At therapeutic concentrations, lithium diminished this muscarinic response, whereas rubidium, which does not affect phosphoinositide metabolism, had no effect. A dampening of phosphoinositide-mediated neurotransmission may explain the normalizing effects of lithium in treating both mania and depression.

Original languageEnglish (US)
Pages (from-to)1428-1429
Number of pages2
JournalScience
Volume239
Issue number4846
StatePublished - 1988

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Phosphatidylinositols
Lithium
Cholinergic Agents
Rubidium
Inositol Phosphates
Mood Disorders
Bipolar Disorder
Synaptic Transmission
Adenosine
Depression
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Lithium blocks a phosphoinositide-mediated cholinergic response in hippocampal slices. / Worley, Paul F; Heller, William A.; Snyder, Solomon H; Baraban, Jay M.

In: Science, Vol. 239, No. 4846, 1988, p. 1428-1429.

Research output: Contribution to journalArticle

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