TY - JOUR
T1 - Lithium administration and phosphate excretion
AU - Arruda, J. A.L.
AU - Richardson, J. M.
AU - Wolfson, J. A.
AU - Nascimento, L.
AU - Rademacher, D. R.
AU - Kurtzman, N. A.
PY - 1976/1/1
Y1 - 1976/1/1
N2 - The phosphaturic effect of parathyroid hormone (PTH), cyclic adenosine monophosphate (cAMP), acetazolamide (Az) and HCO3 loading was studied in normal, thyroparathyroidectomized (TPTX), and Li treated dogs. PTH administration to normal animals markedly increased fractional excretion (F) of PO4 but had a blunted effect on F(po4) in the Li treated animals. Cyclic AMP likewise markedly increased F(po4) in the normal animals but had a markedly blunted effect in the Li treated animals. Az led to a significant increase in F(na), F(hco3), and F(po4) in the normal animals. In the Li treated dogs, Az induced a significant natriuresis and bicarbonaturia but failed to increase phosphaturia. HCO2 loading in normal dogs caused a significant phosphaturia while having little effect on F(po4) in Li treated dogs. HCO3 loading to TPTX dogs was associated with a lower F(po4) as compared to normal HCO3 loaded animals. These data suggest that Li administration not only blocks the adenyl cyclase cAMP system in the renal cortex, but it may also interfere with a step distal to the formation of cAMP, since the phosphaturic effect of both PTH and cAMP was markedly diminished in Li treated animals.
AB - The phosphaturic effect of parathyroid hormone (PTH), cyclic adenosine monophosphate (cAMP), acetazolamide (Az) and HCO3 loading was studied in normal, thyroparathyroidectomized (TPTX), and Li treated dogs. PTH administration to normal animals markedly increased fractional excretion (F) of PO4 but had a blunted effect on F(po4) in the Li treated animals. Cyclic AMP likewise markedly increased F(po4) in the normal animals but had a markedly blunted effect in the Li treated animals. Az led to a significant increase in F(na), F(hco3), and F(po4) in the normal animals. In the Li treated dogs, Az induced a significant natriuresis and bicarbonaturia but failed to increase phosphaturia. HCO2 loading in normal dogs caused a significant phosphaturia while having little effect on F(po4) in Li treated dogs. HCO3 loading to TPTX dogs was associated with a lower F(po4) as compared to normal HCO3 loaded animals. These data suggest that Li administration not only blocks the adenyl cyclase cAMP system in the renal cortex, but it may also interfere with a step distal to the formation of cAMP, since the phosphaturic effect of both PTH and cAMP was markedly diminished in Li treated animals.
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U2 - 10.1152/ajplegacy.1976.231.4.1140
DO - 10.1152/ajplegacy.1976.231.4.1140
M3 - Article
C2 - 185911
AN - SCOPUS:0017183220
VL - 231
SP - 1140
EP - 1146
JO - Advances in Water Resources
JF - Advances in Water Resources
SN - 0309-1708
IS - 4
ER -