Liquid chromatography–tandem mass spectrometry for clinical diagnostics

Stefani N. Thomas; Deborah French; Paul J. Jannetto; Brian A. Rappold; William A. Clarke

doi:10.1038/s43586-022-00175-x

Liquid chromatography–tandem mass spectrometry for clinical diagnostics

Stefani N. Thomas, Deborah French, Paul J. Jannetto, Brian A. Rappold, William A. Clarke

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Mass spectrometry is a powerful analytical tool used for the analysis of a wide range of substances and matrices; it is increasingly utilized for clinical applications in laboratory medicine. This Primer includes an overview of basic mass spectrometry concepts, focusing primarily on tandem mass spectrometry. We discuss experimental considerations and quality management, and provide an overview of some key applications in the clinic. Lastly, the Primer discusses significant challenges for implementation of mass spectrometry in clinical laboratories and provides an outlook of where there are emerging clinical applications for this technology.

Original language	English (US)
Article number	96
Journal	Nature Reviews Methods Primers
Volume	2
Issue number	1
DOIs	https://doi.org/10.1038/s43586-022-00175-x
State	Published - Dec 2022

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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Liquid chromatography–tandem mass spectrometry for clinical diagnostics

Abstract

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