TY - JOUR
T1 - Liquid biopsy for the detection and management of surgically resectable tumors
AU - Blanco, Barbara Aldana
AU - Wolfgang, Christopher L.
N1 - Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/8/15
Y1 - 2019/8/15
N2 - Background: Traditional biopsies have numerous limitations in the developing era of precision medicine, with cancer treatment that relies on biomarkers to guide therapy. Tumor heterogeneity raises the potential for sampling error with the use of traditional biopsy of the primary tumor. Moreover, tumors continuously evolve as new clones arise in the natural course of the disease and under the pressure of treatment. Since traditional biopsy is invasive, it is neither feasible nor practical to perform serial biopsies to guide treatment in real time. Purpose: The current manuscript will review the most commonly used types of liquid biopsy and how these apply to surgical patients in terms of diagnosis, prediction of outcome, and guiding therapy. Conclusions: Liquid biopsy has the potential to overcome many of the limitations of traditional biopsy as a highly tailored, minimally invasive, and cost-effective method to screen and monitor response to treatment. However, many challenges still need to be overcome before liquid biopsy becomes a reliable and widely available option.
AB - Background: Traditional biopsies have numerous limitations in the developing era of precision medicine, with cancer treatment that relies on biomarkers to guide therapy. Tumor heterogeneity raises the potential for sampling error with the use of traditional biopsy of the primary tumor. Moreover, tumors continuously evolve as new clones arise in the natural course of the disease and under the pressure of treatment. Since traditional biopsy is invasive, it is neither feasible nor practical to perform serial biopsies to guide treatment in real time. Purpose: The current manuscript will review the most commonly used types of liquid biopsy and how these apply to surgical patients in terms of diagnosis, prediction of outcome, and guiding therapy. Conclusions: Liquid biopsy has the potential to overcome many of the limitations of traditional biopsy as a highly tailored, minimally invasive, and cost-effective method to screen and monitor response to treatment. However, many challenges still need to be overcome before liquid biopsy becomes a reliable and widely available option.
KW - Cancer
KW - Circulating tumor DNA
KW - Circulating tumor cells
KW - Liquid biopsy
KW - Precision Medicine
KW - Traditional biopsy
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U2 - 10.1007/s00423-019-01788-9
DO - 10.1007/s00423-019-01788-9
M3 - Review article
C2 - 31385024
AN - SCOPUS:85070230116
SN - 1435-2443
VL - 404
SP - 517
EP - 525
JO - Langenbeck's Archives of Surgery
JF - Langenbeck's Archives of Surgery
IS - 5
ER -