The exact cause of liquefaction is not known, but it seems likely that the proteinases, nucleases, and lipases of live and dead macrophages are involved. These hydrolases either diffuse into the caseous area from the periphery or are present initially and are inhibited by substances that gradually disappear from the caseous material. Tubercle bacilli are apparently inhibited in caseous material before liquefaction occurs and grow in tremendous numbers afterward. For this reason, pharmacologic inhibitors to the major hydrolytic enzymes of macrophages possibly could prevent liquefaction or its extension and thus be clinically useful in the management of drug resistant tuberculosis.
|Original language||English (US)|
|Number of pages||3|
|Journal||American Review of Respiratory Disease|
|State||Published - 1976|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine