Lipoxygenase and calcium entry in vascular smooth muscle

P. M. Vanhoutte, P. M.T.J. Rimele, N. A. Flavahan

Research output: Contribution to journalArticlepeer-review

Abstract

In the canine saphenous vein, inhibitors of cyclo-oxygenase augment contractile responses to acetylcholine. potassium chloride and partial α-adrenergie activation. This augmentation is prevented by inhibitors of lipoxygenase, and abolished by calcium entry blockers. These observations suggest that when Ca2+ enters the smooth muscle cells it activates the metabolism of arachidonic acid. If cyclo-oxygenase is inhibited, endproducts of lipoxygenase exert a positive feedback on calcium entry. A similar mechanism may explain the hypoxic contractions observed in various blood vessels, including coronary arteries.

Original languageEnglish (US)
Pages (from-to)S47-S52
JournalJournal of cardiovascular pharmacology
Volume7
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Keywords

  • Calcium entry
  • Lipoxygenase
  • Vascular smooth muscle

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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