Lipoxins: Revelations on resolution

Blaithin McMahon, Siobhan Mitchell, Hugh R. Brady, Catherine Godson

Research output: Contribution to journalReview articlepeer-review

Abstract

Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell-cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered 15-epi-LXs can mimic many of the desirable anti-inflammatory, 'pro-resolution' actions of native LXs. Given the enhanced stability and efficacy of these compounds a role as novel anti-inflammatory therapeutics is proposed.

Original languageEnglish (US)
Pages (from-to)391-395
Number of pages5
JournalTrends in Pharmacological Sciences
Volume22
Issue number8
DOIs
StatePublished - Aug 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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